ArticleMolecular and cellular biology2001
Self-association of CIITA and its transactivation potential.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers.International journal of molecular sciences · 2023Review
- Structural aspects of the MHC expression control system.Biophysical chemistry · 2022Review
- The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.International journal of molecular sciences · 2021Review
- A super enhancer controls expression and chromatin architecture within the MHC class II locus.The Journal of experimental medicine · 2020Article
- CIITA and Its Dual Roles in MHC Gene Transcription.Frontiers in immunology · 2013Article
- Comparative Genomic and Sequence Analysis Provides Insight into the Molecular Functionality of NOD1 and NOD2.Frontiers in immunology · 2013Article
- Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.The Journal of biological chemistry · 2008Article
- HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.International journal of clinical and experimental pathology · 2008Article
- Role of PKCdelta in IFN-gamma-inducible CIITA gene expression.Molecular immunology · 2007Article
- ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.Molecular immunology · 2007Article
- CATERPILLERs, pyrin and hereditary immunological disorders.Nature reviews. Immunology · 2006Review
- Elicitor-mediated oligomerization of the tobacco N disease resistance protein.The Plant cell · 2006Article
- Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters.The EMBO journal · 2002Article
- Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.Molecular and cellular biology · 2002Article
- Function and regulation of class II transactivator in the immune system.Immunologic research · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The major histocompatibility complex (MHC) class II transactivator (CIITA) regulates the expression of genes involved in the immune response, including MHC class II genes and the interleukin-4 gene. Interactions between CIITA and sequence-specific, DNA-binding proteins are required for CIITA to function as an activator of MHC class II genes. CIITA also interacts with the coactivators CBP (also called p300), and this interaction leads to synergistic activation of MHC class II promoters. Here, we report that CIITA forms complexes with itself and that a central region, including the GTP-binding domain is sufficient for self-association. Additionally, this central region interacts with the C-terminal leucine-rich repeat as well as the N-terminal acidic domain. LXXLL motifs residing in the GTP-binding domain are essential for self-association. Finally, distinct differences exist among various CIITA mutant proteins with regard to activation function, subcellular localization, and association with wild-type protein and dominant-negative potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.