ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Membrane bistability in olfactory bulb mitral cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- A family of coexisting multi-scroll chaos and its selected control in coupled non-oscillatory neurons: A case study.Heliyon · 2025Article
- Firing Patterns of Mitral Cells and Their Transformation in the Main Olfactory Bulb.Brain sciences · 2024Article
- Article
- Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Activation of Granule Cell Interneurons by Two Divergent Local Circuit Pathways in the Rat Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Subpopulations of Projection Neurons in the Olfactory Bulb.Frontiers in neural circuits · 2020Review
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- Cannabinoid receptor-mediated modulation of inhibitory inputs to mitral cells in the main olfactory bulb.Journal of neurophysiology · 2019Article
- Neuromodulation of Synaptic Transmission in the Main Olfactory Bulb.International journal of environmental research and public health · 2018Review
- Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Differences in Glomerular-Layer-Mediated Feedforward Inhibition onto Mitral and Tufted Cells Lead to Distinct Modes of Intensity Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells.Frontiers in cellular neuroscience · 2017Article
- The Interglomerular Circuit Potently Inhibits Olfactory Bulb Output Neurons by Both Direct and Indirect Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Serotonin increases synaptic activity in olfactory bulb glomeruli.Journal of neurophysiology · 2016Article
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells.Theoretical biology & medical modelling · 2015Article
- Role of intraglomerular circuits in shaping temporally structured responses to naturalistic inhalation-driven sensory input to the olfactory bulb.Journal of neurophysiology · 2015Article
- Discharge patterning in rat olfactory bulb mitral cells in vivo.Physiological reports · 2014Article
- Identification of both GABAA receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant α-asarone.Frontiers in pharmacology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Whole-cell patch-clamp recordings were used to investigate the electrophysiological properties of mitral cells in rat main olfactory bulb brain slice preparations. The majority of mitral cells are bistable. These cells spontaneously alternate between two membrane potentials, separated by approximately 10 mV: a relatively depolarized potential (upstate), which is perithreshold for spike generation, and a relatively hyperpolarized potential (downstate), in which spikes do not occur. Bistability occurs spontaneously in the absence of ionotropic excitatory or inhibitory synaptic inputs. Bistability is voltage dependent; transition from the downstate to the upstate is a regenerative event activated by brief depolarization. A brief hyperpolarization can switch the membrane potential from the upstate to the downstate. In response to olfactory nerve (ON) stimulation, mitral cells in the upstate are more likely to fire an action potential than are those in the downstate. ON stimulation can switch the membrane potential from the downstate to the upstate, producing a prolonged and amplified depolarization in response to a brief synaptic input. We conclude that bistability is an intrinsic property of mitral cells that is a major determinant of their responses to ON input.
Indexed as
Identifiers
11438607PMC6762867What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.