ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion.The European journal of neuroscience · 2025Review
- Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons.Frontiers in cell and developmental biology · 2025Article
- Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice.Scientific reports · 2024Article
- Understanding the habenula: A major node in circuits regulating emotion and motivation.Pharmacological research · 2023Review
- Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models.Current topics in behavioral neurosciences · 2020Article
- Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior.Scientific reports · 2017Article
- A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders.Behavioural brain research · 2016Review
- An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence.eLife · 2015Article
- Does chronic nicotine consumption influence visual backward masking in schizophrenia and schizotypy?Schizophrenia research. Cognition · 2015Article
- Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking.Frontiers in psychiatry · 2013Article
- Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Article
- Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Decreased cholinergic receptor expression in the striatum: motor function deficit in hypoglycemic and diabetic rats.Cellular and molecular neurobiology · 2012Article
- Expression of cholinergic, insulin, vitamin D receptors and GLUT 3 in the brainstem of streptozotocin induced diabetic rats: effect of treatment with vitamin D₃.Neurochemical research · 2011Article
- Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract.American journal of physiology. Cell physiology · 2011Article
- Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits.Seminars in cell & developmental biology · 2009Review
- Mammalian nicotinic acetylcholine receptors: from structure to function.Physiological reviews · 2009Review
- Effects of nicotine, methamphetamine and cocaine on extracellular levels of acetylcholine in the interpeduncular nucleus of rats.Neuroscience letters · 2008Article
- Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking.Cellular and molecular neurobiology · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Attempts to mimic synaptic delivery of acetylcholine (ACh) with brief, repetitive pulses of high concentration ACh at synapses of medial habenula (MHN) and interpeduncular nucleus (IPN) neurons in vitro elicited temporally distinct facilitation and inhibition of glutamate secretion via nicotinic and muscarinic ACh receptor-mediated pathways, respectively. ACh-induced nicotinic facilitation was sustained for up to 2 hr, whereas muscarinic inhibition was transient. Prolonged exposure to nicotine inactivated nicotinic receptors selectively, thus decreasing the relative contribution of the facilitatory versus inhibitory influences of ACh. The net effect of ACh in modulating glutamatergic transmission at MHN-IPN synapses may be determined by pre-exposure to nicotine, because the drug appears to switch the balance between the facilitatory and inhibitory actions of ACh.
Indexed as
Identifiers
11438593PMC6762872W1847254590What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.