ArticleThe American journal of pathology2001
Morphological interactions of interdigitating dendritic cells with B and T cells in human mesenteric lymph nodes.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease.Immunometabolism (Cobham, Surrey) · 2026Review
- U-DCS: characterization of the first permanent human dendritic sarcoma cell line.Scientific reports · 2020Article
- Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy.Nature communications · 2019Article
- Hollow MnONature communications · 2017Article
- Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.Nature communications · 2016Article
- Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Targeting MARCO can lead to enhanced dendritic cell motility and anti-melanoma activity.Cancer immunology, immunotherapy : CII · 2010Article
- Characterizing the dynamics of CD4+ T cell priming within a lymph node.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Dendritic cell populations in colon and mesenteric lymph nodes of patients with Crohn's disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning.Journal of theoretical biology · 2008Article
- Dendritic cells interacting mainly with B cells in the lymphoepithelial symbiosis of the human palatine tonsil.Virchows Archiv : an international journal of pathology · 2006Article
- Sampling tumor-draining lymph nodes for phenotypic and functional analysis of dendritic cells and T cells.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interdigitating dendritic cells (IDC) of the human mesenteric lymph nodes (LN) were examined by two-color immunofluorescent microscopy and flow cytometry to clarify their exact localization, immunophenotype, and relationships with T and B cells. IDC were identified as HLA-DR(bright) large dendriform cells of the T cell areas co-expressing CD40, CD54 (ICAM-1), CD80 (B7/B7-1), CD83, and CD86 (B70/B7-2). The majority of IDC directly attached to a few IgD+ naive B cells as well as to numerous CD4+ T cells. When LN cells were singly suspended and briefly incubated in vitro, IDC formed clusters with IgD+ IgM+ naive B cells, but not with IgA+ or IgG+ B cells. When suspended LN cells were cultured, clustered B cells disappeared within 7 days, and on prolonged culture, some IDC developed into extensively dendriform cells forming stable complexes with several or sometimes numerous CD4+ IL-2R+ CD40L+ activated T cells. These findings indicate that resting naive B cells actually interact with IDC directly in T cell areas of human secondary lymphoid tissues. IDC have a non-antigen (Ag)-specific, strong affinity for resting naive B cells, but this affinity is transient and IDC cannot form stable complexes with B cells, although they can form stable complexes with activated T cells. It is suggested that the stable IDC/Ag-activated T cell complexes make it possible to capture and to stimulate rare Ag-specific resting naive B cells with high efficiency.
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