ArticleThe American journal of pathology2001
HLA-G and NK receptor are expressed in psoriatic skin: a possible pathway for regulating infiltrating T cells?
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 154 citations in OpenAlex.
- Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan.Molecular medicine reports · 2024Article
- Pharmacogenomics on the Treatment Response in Patients with Psoriasis: An Updated Review.International journal of molecular sciences · 2023Review
- The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients.Biomedicines · 2022Article
- Immunosuppressive Properties of Epidermal Keratinocytes Differ According to Their Immaturity Status.Frontiers in immunology · 2022Article
- Human Keratinocytes Inhibit CD4Cells · 2021Article
- Role and expression of non-classical human leukocyte antigen-G in renal transplanted allografts.Clinical and experimental nephrology · 2021Article
- HLA-G in Allergy: Does It Play an Immunoregulatory Role?Frontiers in immunology · 2021Review
- Skin Immunity and Tolerance: Focus on Epidermal Keratinocytes Expressing HLA-G.Frontiers in immunology · 2021Review
- B Cells Control Mucosal-Associated Invariant T Cell Responses toFrontiers in immunology · 2021Article
- HLA-G Expressing Immune Cells in Immune Mediated Diseases.Frontiers in immunology · 2020Review
- HLA-G Neo-Expression on Tumors.Frontiers in immunology · 2020Review
- Analysis of circulating soluble programmed death 1 (PD-1), neuropilin 1 (NRP-1) and human leukocyte antigen-G (HLA-G) in psoriatic patients.Postepy dermatologii i alergologii · 2019Article
- Stem Cells as Potential Candidates for Psoriasis Cell-Replacement Therapy.International journal of molecular sciences · 2017Review
- Immunoregulatory Role of HLA-G in Allergic Diseases.Journal of immunology research · 2016Review
- Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases.Journal of immunology research · 2016Review
- Trogocytic intercellular membrane exchanges among hematological tumors.Journal of hematology & oncology · 2015Article
- The paradox of high availability and low recognition of soluble HLA-G by LILRB1 receptor in rheumatoid arthritis patients.PloS one · 2015Article
- Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity.Frontiers in immunology · 2014Article
- Synthetic HLA-G proteins for therapeutic use in transplantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors.Cellular and molecular life sciences : CMLS · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent data have suggested that in psoriasis, the T-infiltrating cells could be submitted to regulatory pathways, possibly through natural killer receptors. HLA-G binds to different natural killer receptors and is able to inhibit T-cell functions. Because this molecule is induced by interferon-gamma, a major cytokine in psoriasis, we asked whether HLA-G and its receptor might be expressed in this disease. Specific RNAs for HLA-G1 and HLA-G5 were consistently found in lesional skin specimens, soluble HLA-G5 transcripts being found only in psoriasis. HLA-G protein was found in all psoriatic sections, but never in normal skin controls. Double labeling demonstrated that HLA-G-positive cells were CD68(+), CD11c(+) macrophages. The NKR ILT2 was also present in psoriatic skin, the T CD4(+)-infiltrating cells expressing indeed ILT2. The demonstration of HLA-G and ILT2 expression in psoriatic skin suggests that this pathway may act as an inhibitory feed back aimed to down-regulate the deleterious effects of T-cell infiltrate in this disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.