ArticleArthritis research2001
Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection.
Article in Arthritis research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- U1 Small Nuclear Ribonucleoprotein Autoantibodies Reflect the Disruption of the Blood-Nerve Barrier in Guillain-Barré Syndrome.International journal of molecular sciences · 2026Article
- Small Nuclear Ribonucleoprotein Autoantibody Associated With Blood-Nerve Barrier Breakdown in Guillain-Barré Syndrome.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Integrating clinical data and genetic susceptibility to elucidate the relationship between systemic lupus erythematosus and human cytomegalovirus infection.Virology journal · 2024Article
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- Cytomegalovirus-Associated Autoantibody against TAF9 Protein in Patients with Systemic Lupus Erythematosus.Journal of clinical medicine · 2021Article
- Review
- Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus.Scientific reports · 2019Article
- B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice.Arthritis research & therapy · 2017Article
- Strong viral associations with SLE among Filipinos.Lupus science & medicine · 2017Article
- Systemic lupus erythematous revealed by cytomegalovirus infection.The Pan African medical journal · 2016Article
- Correlation between systemic lupus erythematosus and cytomegalovirus infection detected by different methods.Clinical rheumatology · 2015Article
- Human cytomegalovirus and autoimmune disease.BioMed research international · 2014Review
- Cytomegalovirus infection in childhood-onset systemic lupus erythematosus.International journal of clinical rheumatology · 2013Article
- Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice.Arthritis research & therapy · 2011Article
- Cytomegalovirus infection in pediatric rheumatic diseases: a review.Pediatric rheumatology online journal · 2010Article
- Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies.Arthritis research & therapy · 2009Article
- Human cytomegalovirus pp65 lower matrix protein: a humoral immunogen for systemic lupus erythematosus patients and autoantibody accelerator for NZB/W F1 mice.Clinical and experimental immunology · 2006Article
- The genotype of mice influences the autoimmune response to spliceosome proteins induced by cytomegalovirus gB immunization.Clinical and experimental immunology · 2002Article
- Lack of autoantibody production associated with cytomegalovirus infection.Arthritis research · 2002Article
- Autoimmunity in Infection-Related Glomerulonephritis.Glomerular diseasesArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction of autoantibodies to U1 small nuclear ribonucleoprotein (U1 snRNP) complexes is not well understood. We present evidence that healthy individuals with cytomegalovirus (CMV) infection have an increased frequency and quantity of antibodies to ribonucleoprotein, directed primarily against the U1-70k protein. A significant association between the presence of antibodies to CMV and antibodies to the total RNP targeted by the immune response to the spliceosome (to both the Sm and RNP; Sm/RNP) was found for patients with systemic lupus erythematosus (SLE) but not those with mixed connective-tissue disease. CMV thus may play a role in inducing autoimmune responses in a subset of patients with systemic lupus erythematosus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.