Evidence map›Paper›PMID 11435598›Full record

ArticleJournal of virology2001

Lipid rafts and pseudotyping.

W F Pickl, F X Pimentel-Muiños, B Seed

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 160 citations in OpenAlex.

  1. Review
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  3. Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound.Proceedings of the National Academy of Sciences of the United States of America · 2023
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  4. Neutral sphingomyelinase 2 is required for HIV-1 maturation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Ceramide and Related Molecules in Viral Infections.International journal of molecular sciences · 2021
    Review
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  8. Review
  9. Review
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  11. Article
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  14. Review
  15. Article
  16. Article
  17. Article
  18. HIV type 1 Gag as a target for antiviral therapy.AIDS research and human retroviruses · 2012
    Review
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

W F PicklDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
F X Pimentel-Muiños
B Seed
Massachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific interactions between envelope and core proteins govern the membrane assembly of most enveloped viruses. Despite this, mixed infections lead to pseudotyping, the association of the viral cores of one virus with the envelopes of another. How does this occur? We show here that the detergent-insoluble lipid rafts of the plasma membrane function as a natural meeting point for the transmembrane and core components of a phylogenetically diverse collection of enveloped viruses. As a result, viral particles preferentially incorporate both the envelope components of other viruses as well as the extra- and intracellular constituents of host cell lipid rafts, including gangliosides, glycosyl phosphatidylinositol-anchored surface proteins, and intracellular signal transduction molecules. Pharmacological disruption of lipid rafts interferes with virus production.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntigens, CDCell FractionationCell Line, TransformedCholesterolDetergentsG(M1) GangliosideGRB2 Adaptor ProteinHumansHuman T-lymphotropic virus 1Membrane MicrodomainsMiceMoloney murine leukemia virusOctoxynolProteinsAdaptor Proteins, Signal TransducingAntigens, CDCholesterolDetergentsG(M1) GangliosideGRB2 Adaptor ProteinGRB2 protein, humanGrb2 protein, mouseOctoxynolProteinsProto-Oncogene Proteins pp60(c-src)ras ProteinsViral Core ProteinsViral Envelope Proteins

Identifiers

PMID11435598
PMCPMC114446
OpenAlexW2154394294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.