ArticleJournal of virology2001
Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Post-translational modifications in PrP expand the conformational diversity of prions in vivo.Scientific reports · 2017Article
- Follicular dendritic cells: dynamic antigen libraries.Nature reviews. Immunology · 2014Review
- Myositis facilitates preclinical accumulation of pathological prion protein in muscle.Acta neuropathologica communications · 2013Article
- The immunobiology of prion diseases.Nature reviews. Immunology · 2013Review
- Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.PLoS pathogens · 2012Article
- Biological effects and use of PrPSc- and PrP-specific antibodies generated by immunization with purified full-length native mouse prions.Journal of virology · 2011Article
- Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model.PloS one · 2010Article
- Chronic wasting disease prions in elk antler velvet.Emerging infectious diseases · 2009Article
- Antiprion prophylaxis by gene transfer of a soluble prion antagonist.The American journal of pathology · 2008Article
- Article
- The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.Journal of neurovirology · 2007Article
- Early and rapid engraftment of bone marrow-derived microglia in scrapie.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Prion diseases and the gastrointestinal tract.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Review
- Prion diseases: current understanding of epidemiology and pathogenesis, and therapeutic advances.CNS drugs · 2006Review
- Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.The Journal of clinical investigation · 2004Article
- Current concepts and controversies in prion immunopathology.Journal of molecular neuroscience : MN · 2004Review
- Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes.The American journal of pathology · 2003Article
- Prion pathogenesis in the absence of Toll-like receptor signalling.EMBO reports · 2003Article
- Transgenesis applied to transmissible spongiform encephalopathies.Transgenic research · 2002Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Defects in hematopoietic compartments, such as impaired B-cell maturation, or in stromal compartments, such as abrogation of follicular dendritic cells, can delay or prevent lymphoreticular prion colonization. However, the nature of the compartment in which prion replication takes place is controversial, and it is unclear whether this compartment coincides with that expressing the normal prion protein (PrP(c)). Here we studied the distribution of infectivity in splenic fractions of wild-type and fetal liver chimeric mice carrying the gene that encodes PrP(c) (Prnp) solely on hematopoietic or on stromal cells. We fractionated spleens at various times after intraperitoneal challenge with prions and assayed infectivity by bioassay. Upon high-dose challenge, chimeras carrying PrP(c) on hematopoietic cells accumulated prions in stroma and in purified splenocytes. In contrast, after low-dose challenge ablation of Prnp in either compartment prevented splenic accumulation of infectivity, indicating that optimal prion replication requires PrP(c) expression by both stromal and hematopoietic compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.