ArticleJournal of virology2001
Hairpin loop structure in the 3' arm of the influenza A virus virion RNA promoter is required for endonuclease activity.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Article
- Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses.Journal of virology · 2019Article
- Single-molecule fluorescence imaging: Generating insights into molecular interactions in virology.Journal of biosciences · 2018Review
- Structural and Functional Motifs in Influenza Virus RNAs.Frontiers in microbiology · 2018Review
- Influenza virus activation of the interferon system.Virus research · 2015Review
- Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export.Journal of virology · 2014Article
- Recombinant influenza A viruses with enhanced levels of PB1 and PA viral protein expression.Journal of virology · 2012Article
- Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.The Journal of biological chemistry · 2011Article
- Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.The Journal of biological chemistry · 2010Article
- Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription.Journal of virology · 2008Article
- Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro.Journal of virology · 2007Article
- The Bunyamwera virus mRNA transcription signal resides within both the 3' and the 5' terminal regions and allows ambisense transcription from a model RNA segment.Journal of virology · 2005Article
- Role of the conserved nucleotide mismatch within 3'- and 5'-terminal regions of Bunyamwera virus in signaling transcription.Journal of virology · 2005Article
- Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication.Journal of virology · 2004Article
- Bunyamwera bunyavirus RNA synthesis requires cooperation of 3'- and 5'-terminal sequences.Journal of virology · 2004Article
- Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis.The EMBO journal · 2003Article
- A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase.Nucleic acids research · 2003Article
- Mutational analysis of the Uukuniemi virus (Bunyaviridae family) promoter reveals two elements of functional importance.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that the 5' arm of the influenza A virus virion RNA promoter requires a hairpin loop structure for efficient endonuclease activity of influenza virus RNA polymerase, an activity that is required for the cap-snatching activity of primers from host pre-mRNA. Here we examine whether a hairpin loop is also required in the 3' arm of the viral RNA promoter. We study point mutations at each nucleotide position (1 to 12) within the 3' arm of the promoter as well as complementary "rescue" mutations which restored base pairing in the stem of a potential hairpin loop. Our results suggest that endonuclease activity is absolutely dependent on the presence of a 3' hairpin loop structure. This is the first direct evidence for RNA secondary structure within the 3' arm being required for a specific stage, i.e., endonuclease cleavage, in the influenza virus replicative cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.