ArticleGenome research2001
The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
- The genetics of adaptation in freshwater Eurasian shad (Ecology and evolution · 2022Article
- Genetically altered animal models for ATP1A3-related disorders.Disease models & mechanisms · 2021Article
- A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals andScience advances · 2020Article
- NaJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- NaJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Article
- Distinct neurological disorders with ATP1A3 mutations.The Lancet. Neurology · 2014Review
- Differential expression of Na+, K(+)-ATPase α-1 isoforms during seawater acclimation in the amphidromous galaxiid fish Galaxias maculatus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish.The Journal of biological chemistry · 2013Article
- Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.PloS one · 2013Article
- Article
- Ion flux dependent and independent functions of ion channels in the vertebrate heart: lessons learned from zebrafish.Stem cells international · 2012Article
- Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides.PloS one · 2012Article
- Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish.Developmental biology · 2008Article
- Importance for absorption of Na+ from freshwater of lysine, valine and serine substitutions in the alpha1a-isoform of Na,K-ATPase in the gills of rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar).The Journal of membrane biology · 2008Article
- Characterization of Na, K-ATPase genes in Atlantic salmon (Salmo salar) and comparative genomic organization with rainbow trout (Oncorhynchus mykiss).Molecular genetics and genomics : MGG · 2005Article
- Stimulation of sodium pump restores membrane potential to neurons excited by glutamate in zebrafish distal retina.The Journal of physiology · 2003Article
- The zebrafish annexin gene family.Genome research · 2003Article
- Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.Genome research · 2001Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a cohort of zebrafish expressed sequence tags encoding eight Na,K-ATPase alpha subunits and five beta subunits. Sequence comparisons and phylogenetic analysis indicate that five of the zebrafish alpha subunit genes comprise an alpha1-like gene subfamily and two are orthologs of the mammalian alpha3 subunit gene. The remaining alpha subunit clone is most similar to the mammalian alpha2 subunit. Among the five beta subunit genes, two are orthologs of the mammalian beta1 isoform, one represents a beta2 ortholog, and two are orthologous to the mammalian beta3 subunit. Using zebrafish radiation hybrid and meiotic mapping panels, we determined linkage assignments for each alpha and beta subunit gene. Na,K-ATPase genes are dispersed in the zebrafish genome with the exception of four of the alpha1-like genes, which are tightly clustered on linkage group 1. Comparative mapping studies indicate that most of the zebrafish Na,K-ATPase genes localize to regions of conserved synteny between zebrafish and humans. The expression patterns of Na,K-ATPase alpha and beta subunit genes in zebrafish are quite distinctive. No two alpha or beta subunit genes exhibit the same expression profile. Together, our data imply a very high degree of Na,K-ATPase isoenzyme heterogeneity in zebrafish, with the potential for 40 structurally distinct alpha/beta subunit combinations. Differences in expression patterns of alpha and beta subunits suggest that many of the isoenzymes are also likely to exhibit differences in functional properties within specific cell and tissue types. Our studies form a framework for analyzing structure function relationships for sodium pump isoforms using reverse genetic approaches.
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