ReviewJournal of biotechnology2001
Coronavirus derived expression systems.
Review in Journal of biotechnology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Development of SARS-CoV-2 as a viral vector: A novel intranasal bivalent vaccine for SARS-CoV-2 and RSV.Science advances · 2025Article
- RNA interference as a promising treatment against SARS-CoV-2.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Research Progress on Coronavirus Prevention and Control in Animal-Source Foods.Journal of multidisciplinary healthcare · 2020Review
- Phages bearing affinity peptides to severe acute respiratory syndromes-associated coronavirus differentiate this virus from other viruses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2013Article
- Complete genome sequence of a novel porcine epidemic diarrhea virus in south China.Journal of virology · 2012Article
- Characterization and complete genome sequence of human coronavirus NL63 isolated in China.Journal of virology · 2012Article
- Complete genome sequence of a Chinese virulent porcine epidemic diarrhea virus strain.Journal of virology · 2011Article
- Partial deletion in the spike endodomain of mouse hepatitis virus decreases the cytopathic effect but maintains foreign protein expression in infected cells.Journal of virological methods · 2011Article
- Vectored vaccines to protect against PRRSV.Virus research · 2010Review
- Molecular mechanisms of viral infection and propagation: an overview of the second Advanced Summer School in Africa.IUBMB life · 2010Review
- Towards construction of viral vectors based on avian coronavirus infectious bronchitis virus for gene delivery and vaccine development.Journal of virological methods · 2009Article
- Human coronavirus infection among children with acute lower respiratory tract infection in Thailand.Intervirology · 2007Article
- The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages.Immunobiology · 2007Article
- Efficient transduction of dendritic cells using coronavirus-based vectors.Advances in experimental medicine and biology · 2006Article
- Soluble receptor-mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor.Journal of virology · 2005Article
- Coronaviruses as vectors: stability of foreign gene expression.Journal of virology · 2005Article
- Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccines.The journal of gene medicine · 2005Review
- Coronavirus reverse genetics and development of vectors for gene expression.Current topics in microbiology and immunology · 2005Review
- Molecular interactions in the assembly of coronaviruses.Advances in virus research · 2005Article
- Coronavirus spike glycoprotein, extended at the carboxy terminus with green fluorescent protein, is assembly competent.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both helper dependent expression systems, based on two components, and single genomes constructed by targeted recombination, or by using infectious cDNA clones, have been developed. The sequences that regulate transcription have been characterized mainly using helper dependent expression systems and it will now be possible to validate them using single genomes. The genome of coronaviruses has been engineered by modification of the infectious cDNA leading to an efficient (>20 microg ml(-1)) and stable (>20 passages) expression of the foreign gene. The possibility of engineering the tissue and species tropism to target expression to different organs and animal species, including humans, increases the potential of coronaviruses as vectors. Thus, coronaviruses are promising virus vectors for vaccine development and, possibly, for gene therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.