ArticleBreast cancer research : BCR2001
In vivo cell kinetics in breast carcinogenesis.
Article in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.Genome biology · 2013Trial
- Case Report: Breast ductal carcinomaFrontiers in oncology · 2025Article
- Immune landscape of the tumour microenvironment in Ethiopian breast cancer patients.Breast cancer research : BCR · 2024Article
- Evaluation of cleaved caspase-3 and Ki-67 index on diagnostic biopsy in response to neoadjuvant chemotherapy in the context of post-treatment tumour ypT stage, ypN stage, grade, and molecular subtype.Przeglad menopauzalny = Menopause review · 2024Article
- Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling.Nature immunology · 2020Article
- Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Aberrant BLID expression is associated with breast cancer progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- The enigmatic roles of caspases in tumor development.Cancers · 2010Article
- Expression of matrix metalloproteinase-10 in non-metastatic prostate cancer: Correlation with an imbalance in cell proliferation and apoptosis.Oncology letters · 2010Article
- Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma.World journal of surgical oncology · 2007Review
- Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions.Critical care (London, England) · 2006Article
- Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.Breast cancer research : BCR · 2006Article
- Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS).Endocrine pathology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal epithelium, hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis. MATERIALS AND
methodsA total of 32 areas of apparently normal epithelium and 135 ductal proliferative and neoplastic lesions were studied. More than one epithelial lesion per case were analyzed. The apoptotic index (AI) and the proliferative index (PI) were expressed as the percentage of TdT-mediated dUTP-nick end-labelling (TUNEL) and Ki-67-positive cells, respectively. The PI/AI (P/A index) was calculated for each case.
resultsThe AIs and PIs were significantly higher in hyperplasia than in apparently normal epithelium (P = 0.04 and P = 0.0005, respectively), in atypical hyperplasia than in hyperplasia (P = 0.01 and P = 0.04, respectively) and in invasive carcinoma than in in situ carcinoma (P < 0.001 and P < 0.001, respectively). The two indices were similar in atypical hyperplasia and in in situ carcinoma. The P/A index increased significantly from normal epithelium to hyperplasia (P = 0.01) and from preinvasive lesions to invasive carcinoma (P = 0.04) whereas it was decreased (non-significantly) from hyperplasia to preinvasive lesions. A strong positive correlation between the AIs and the PIs was found (r = 0.83, P < 0.001).
conclusionThese findings suggest accelerating cell turnover along the continuum of breast carcinogenesis. Atypical hyperplasias and in situ carcinomas might be kinetically similar lesions. In the transition from normal epithelium to hyperplasia and from preinvasive lesions to invasive carcinoma the net growth of epithelial cells results from a growth imbalance in favour of proliferation. In the transition from hyperplasia to preinvasive lesions there is an imbalance in favour of apoptosis.
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Identifiers
11434879PMC34112W2106551486What OpenQuestion holds
Registered trials
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