ReviewBreast cancer research : BCR2001
Tumour-stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis.
Review in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
- The role of genetics in estrogen responses: a critical piece of an intricate puzzle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Review
- Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland.Endocrinology · 2014Article
- Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer.Journal of mammary gland biology and neoplasia · 2014Review
- Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model.Cancer letters · 2014Article
- Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution.Breast cancer research : BCR · 2013Article
- Roles of EphA2 in Development and Disease.Genes · 2013Article
- Inhibitory morphogens and monopodial branching of the embryonic chicken lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.Journal of mammary gland biology and neoplasia · 2011Review
- A compendium of the mouse mammary tumor biologist: from the initial observations in the house mouse to the development of genetically engineered mice.Cold Spring Harbor perspectives in biology · 2011Article
- Role of TGF-β and the tumor microenvironment during mammary tumorigenesis.Gene expression · 2011Review
- Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes.Developmental biology · 2010Article
- The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis.Developmental biology · 2009Article
- Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase.Molecular biology of the cell · 2009Article
- Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.The American journal of pathology · 2009Article
- Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion.Molecular cancer research : MCR · 2008Article
- Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.Developmental biology · 2008Article
- Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages.The Journal of experimental medicine · 2008Article
- Colostrum TGF-beta-1 associates with the duration of breast-feeding.European journal of nutrition · 2007Article
- Mammary gland involution as a multi-step process.Journal of mammary gland biology and neoplasia · 2007Review
- Comparative mechanisms of branching morphogenesis in diverse systems.Journal of mammary gland biology and neoplasia · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The mammary gland undergoes morphogenesis through the entire reproductive life of mammals. In mice, ductal outgrowth from the nipple across the fat pad results in an intricate, well spaced ductal tree that further ramifies and develops alveolar structures during pregnancy. Ductal morphogenesis is regulated by the concerted action of circulating steroid and polypeptide hormones, and local epithelial-mesenchymal inductive signals. Transforming growth factor (TGF)-beta1-3 and hepatocyte growth factor (HGF)/scatter factor (SF) are important components of this latter signaling pathway. TGF-beta1 and TGF-beta3 have roles in both promotion and inhibition of branching morphogenesis that are dependent on concentration and context. HGF/SF promotes ductal outgrowth and tubule formation in the mammary gland. These data suggest that these two growth factors have complementary roles in promoting mammary ductal morphogenesis and in maintaining ductal spacing. In addition, TGF-beta3 triggers apoptosis in the alveolar epithelia, which is a necessary component of mammary gland involution and return of the ductal structure to a virgin-like state after lactation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.