ReviewBreast cancer research : BCR2001
Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.
Review in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- Clinical significance of integrin αV and β superfamily members and focal adhesion kinase activity in oral squamous cell carcinoma: a retrospective observational study.Pathology oncology research : POR · 2024Observational
- Fast ICCD-based temperature modulated fluorescence tomography.Applied optics · 2023Article
- Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?Cancers · 2021Review
- Article
- Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimickingTheranostics · 2018Review
- From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.Cancer metastasis reviews · 2016Article
- Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.Neuro-oncology · 2013Article
- The role of tumour-stromal interactions in modifying drug response: challenges and opportunities.Nature reviews. Drug discovery · 2013Review
- Co-implanting orthotopic tissue creates stroma microenvironment enhancing growth and angiogenesis of multiple tumors.F1000Research · 2013Article
- Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.Cancer letters · 2012Article
- β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib.Breast cancer research : BCR · 2011Article
- Article
- Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.Journal of experimental & clinical cancer research : CR · 2010Article
- Biomechanical regulation of cell orientation and fate.Oncogene · 2008Review
- Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats.Environmental health perspectives · 2007Article
- Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy.Neoplasia (New York, N.Y.) · 2006Article
- Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion.Oncogene · 2005Article
- A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.American journal of respiratory cell and molecular biology · 2005Article
- The tension mounts: mechanics meets morphogenesis and malignancy.Journal of mammary gland biology and neoplasia · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Stromal-epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue homeostasis and enhanced survival phenotype of the disease. Apoptosis resistance likely arises during malignant transformation via genetic and epigenetic modification of cell adhesion pathways induced by a changing tissue microenvironment. Acquisition of adhesion-linked survival networks that enhance MEC viability in the absence of basement membrane interactions probably promote malignant transformation, and may render breast tumors sufficiently resistant to exogenous apoptotic stimuli to generate multidrug resistance.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.