ReviewBreast cancer research : BCR2001
Tumour-stromal interactions. Role of the stroma in mammary development.
Review in Breast cancer research : BCR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Review
- Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation.Journal of cell science · 2023Article
- Minireview: Parabens Exposure and Breast Cancer.International journal of environmental research and public health · 2022Review
- Metabolic Stress Adaptations Underlie Mammary Gland Morphogenesis and Breast Cancer Progression.Cells · 2021Review
- Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland.Current biology : CB · 2021Article
- Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells.Cancers · 2020Review
- Review
- Three-Dimensional Patient-DerivedFrontiers in oncology · 2017Review
- Prediction of individual response to anticancer therapy: historical and future perspectives.Cellular and molecular life sciences : CMLS · 2015Review
- Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state.PLoS computational biology · 2014Article
- Methods of Cell Propulsion through the Local Stroma in Breast Cancer.International journal of breast cancer · 2014Review
- Host epithelial geometry regulates breast cancer cell invasiveness.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dynamics of branched tissue assembly.Stem cell research & therapy · 2012Review
- The mammary gland microenvironment directs progenitor cell fate in vivo.International journal of cell biology · 2011Article
- Cell density is a critical determinant of aromatase expression in adipose stromal cells.The Journal of steroid biochemistry and molecular biology · 2010Article
- The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.Breast cancer research : BCR · 2010Review
- Article
- Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment.BMC cancer · 2006Article
- Breast cancer, stem cells and prospects for therapy.Breast cancer research : BCR · 2006Review
- The serine/threonine kinase, Krct, affects endbud morphogenesis during murine mammary gland development.Transgenic research · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammary development depends on branching morphogenesis, namely the bifurcation and extension of ductal growth points (end buds) and secretory lobules into a more or less fatty stroma. Because breast carcinomas are overwhelmingly ductal in origin, this review focuses on stromal influences guiding postnatal ductal development and there is only the briefest account of the role of embryonic stroma (mesenchyme). The stroma as the necessary target for endocrine mammogens and the source of stimulatory growth factors is described and the importance of mammary epithelium-induced modifications of the periductal stroma is emphasized. Evidence is presented that if they are to grow, end buds must condition proximal fatty stroma by recruiting white blood cells as well as inducing stromal cell division and, possibly, estrogen receptors. The induction of a fibrous stromal tunic around the end bud is described and its likely role as a complex ductal morphogen is discussed; a possible role in growth inhibition is also considered. Although the signals governing fibrotic induction, ductal morphogenesis, and growth inhibition are unknown, a role for transforming growth factor-beta is highly likely and is discussed. Finally, a need for new conceptual and experimental approaches to understanding stromal-epithelial signaling is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.