Evidence map›Paper›PMID 11433040›Full record

ArticleNucleic acids research2001

The mapping of nucleosomes and regulatory protein binding sites at the Saccharomyces cerevisiae MFA2 gene: a high resolution approach.

Y Teng, S Yu, R Waters

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus.Proceedings of the National Academy of Sciences of the United States of America · 2005
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Y TengSchool of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK.
S Yu
R Waters
Swansea University · GB

Funding

Medical Research Council G9900118
6 · The paper itself

Abstract

We have developed an end-labelling approach to map the positions of nucleosomes and protein binding sites at nucleotide resolution by footprinting micrococcal nuclease (MNase)-sensitive sites. Using this approach we determined that the MFA2 gene and its upstream control regions have four positioned nucleosomes when transcription is repressed in mating type alpha cells and that the nucleosomes lose their positioning when the gene became transcriptionally active in mating type a cells. We also detected MNase-hypersensitive sites in the alpha2 operator region of MFA2 in alpha cells but not in a cells. These probably result from the change in the local DNA conformation due to protein(s) binding in this region that governs MFA2 transcription.

Indexed as

Base SequenceBinding SitesDNA-Binding ProteinsDNA FootprintingDNA, FungalDNA ProbesFungal ProteinsGene Expression Regulation, FungalGenes, FungalGene SilencingGenes, Mating Type, FungalLipoproteinsMicrococcal NucleaseMolecular ConformationNucleosomesPheromonesDNA-Binding ProteinsDNA, FungalDNA ProbesFungal ProteinsLipoproteinsMFA2 protein, S cerevisiaeMicrococcal NucleaseNucleosomesPheromonesProtein PrecursorsRNA, FungalRNA, MessengerSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID11433040
PMCPMC55788
OpenAlexW2143953005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.