ArticleNucleic acids research2001
Developmentally-regulated packaging of mitochondrial DNA by the HMG-box protein mtTFA during Xenopus oogenesis.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei.Biophysics reports · 2023Article
- High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.Life science alliance · 2021Article
- Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence.Oxidative medicine and cellular longevity · 2020Article
- Modeling RNA polymerase interaction in mitochondria of chordates.Biology direct · 2012Article
- Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mitochondrial DNA transcription regulation and nucleoid organization.Journal of inherited metabolic disease · 2011Review
- In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions.Nucleic acids research · 2009Article
- Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression.Cell cycle (Georgetown, Tex.) · 2007Article
- Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.Nucleic acids research · 2007Article
- Subcellular in vivo 1H MR spectroscopy of Xenopus laevis oocytes.Biophysical journal · 2006Article
- The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae.Molecular biology of the cell · 2005Article
- Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA.Nucleic acids research · 2003Article
- Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein.EMBO reports · 2002Article
- Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells.Nucleic acids research · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mature Xenopus oocytes are highly enriched for mitochondria. The organelles are stored and partitioned to newly-arising cells during embryogenesis, when there is little mitochondrial DNA (mtDNA) replication or transcription. A previously described member of the high mobility group (HMG) family of proteins, mtTFA, has been suggested to play a role in control of mtDNA copy number. mtTFA serves as a mitochondrial transcription factor in humans and Xenopus and as an abundant mtDNA packaging protein in yeast, like its prokaryotic histone-like counterpart, HU protein. Northern blot analysis demonstrated that expression of the gene was regulated during Xenopus oogenesis and specifically peaked at stage II. Western and Southern blotting were used to quantify amounts of the protein and mtDNA, respectively, in each stage of oogenesis. mtTFA:mtDNA ratios were found to be relatively low in previtellogenic oocytes while the ratios increased markedly in mature oocytes.
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Registered trials
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