ArticleNucleic acids research2001
Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Regulation of Genome Architecture in Huntington's Disease.Biochemistry · 2025Article
- Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.BMC biology · 2024Article
- Roles of Histone H2A Variants in Cancer Development, Prognosis, and Treatment.International journal of molecular sciences · 2024Review
- Nuclear envelope, chromatin organizers, histones, and DNA: The many achilles heels exploited across cancers.Frontiers in cell and developmental biology · 2022Review
- Old cogs, new tricks: the evolution of gene expression in a chromatin context.Nature reviews. Genetics · 2019Review
- Analysis of mRNA abundance for histone variants, histone- and DNA-modifiers in bovine in vivo and in vitro oocytes and embryos.Scientific reports · 2019Article
- MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20.Nature communications · 2018Article
- Variable escape from X-chromosome inactivation: identifying factors that tip the scales towards expression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Histone variants: dynamic punctuation in transcription.Genes & development · 2014Review
- Article
- Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains.PloS one · 2012Article
- Evolutionary diversity and developmental regulation of X-chromosome inactivation.Human genetics · 2011Review
- PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation.The Journal of biological chemistry · 2011Article
- Histone variants in metazoan development.Developmental cell · 2010Review
- X chromosome inactivation and autoimmunity.Clinical reviews in allergy & immunology · 2010Review
- MacroH2A subtypes contribute antagonistically to the transcriptional regulation of the ribosomal cistron during seasonal acclimatization of the carp fish.Epigenetics & chromatin · 2010Article
- MacroH2A1 knockdown effects on the Peg3 imprinted domain.BMC genomics · 2007Article
- The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome.Journal of molecular biology · 2007Article
- Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome.The EMBO journal · 2006Article
- Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Microbiology and molecular biology reviews : MMBR · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin on the inactive X chromosome (Xi) of female mammals is enriched for the histone variant macroH2A that can be detected at interphase as a distinct nuclear structure referred to as a macro chromatin body (MCB). Green fluorescent protein-tagged and Myc epitope-tagged macroH2A readily form an MCB in the nuclei of transfected female, but not male, cells. Using targeted disruptions, we have identified two macrochromatin domains within macroH2A that are independently capable of MCB formation and association with the Xi. Complete removal of the non-histone C-terminal tail does not reduce the efficiency of association of the variant histone domain of macroH2A with the Xi, indicating that the histone portion alone can target the Xi. The non-histone domain by itself is incapable of MCB formation. However, when directed to the nucleosome by fusion to core histone H2A or H2B, the non-histone tail forms an MCB that appears identical to that of the endogenous protein. Mutagenesis of the non-histone portion of macroH2A localized the region required for MCB formation and targeting to the Xi to an approximately 190 amino acid region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.