Evidence map›Paper›PMID 11432882›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2001

Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study.

A C Mertens, Y Yasui, J P Neglia, J D Potter, M E Nesbit, K Ruccione, W A Smithson, L L Robison

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02114697 (Accelerated Atherosclerosis in High Risk Population Groups), which is not on this map. Cited by 244 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
244citing papers in PubMed, 13 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02114697 phase4terminatedstarted 2014, after this paper: background citation

Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging

Ran2014Enrolled9Registered outcomes1Posted comparisons0ConditionsAtherosclerosisArmsLifestyle Modification, Statin therapy
PMID 18997196PMID 15135672PMID 10865837PMID 10961958PMID 11181465PMID 11687667PMID 11773180PMID 11877368PMID 12368635PMID 12476646PMID 12490960PMID 12655579other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

244 citing papers in PubMed, 13 syntheses or guidelines pooled it, 802 citations in OpenAlex.

  1. Pooled it
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  5. Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
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  9. Metabolic syndrome in hematologic malignancies survivors: a meta-analysis.Medical oncology (Northwood, London, England) · 2015
    Pooled it
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  11. Considering quality of life for children with cancer: a systematic review of patient-reported outcome measures and the development of a conceptual model.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014
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  13. Guideline
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  20. Quantifying Survival and Mortality in Childhood Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article

184 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A C MertensDepartment of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, USA. mertens@epi.umn.edu
Y Yasui
J P Neglia
J D Potter
M E Nesbit
K Ruccione
W A Smithson
L L Robison
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZA

Funding

Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
CHILDHOOD CANCER SURVIVOR STUDYU01CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROBISON, LESLIE L · 1993 to 1999
–
NCI NIH HHS CA 55727NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

purposeSurvivors of childhood and adolescent cancer are at risk for long-term effects of disease and treatment. The Childhood Cancer Survivor Study assessed overall and cause-specific mortality in a retrospective cohort of 20,227 5-year survivors. PATIENTS AND

methodsEligible subjects were individuals diagnosed with cancer (from 1970 to 1986) before the age of 21 who had survived 5 years from diagnosis. Underlying cause of death was obtained from death certificates and other sources and coded and categorized as recurrent disease, sequelae of cancer treatment, or non-cancer-related. Age and sex standardized mortality ratios (SMRs) were calculated using United States population mortality data.

resultsThe cohort, including 208,947 person-years of follow-up, demonstrated a 10.8-fold excess in overall mortality (95% confidence interval, 10.3 to 11.3). Risk of death was statistically significantly higher in females (SMR = 18.2), individuals diagnosed with cancer before the age of 5 years (SMR = 14.0), and those with an initial diagnosis of leukemia (SMR = 15.5) or CNS tumor (SMR = 15.7). Recurrence of the original cancer was the leading cause of death among 5-year survivors, accounting for 67% of deaths. Statistically significant excess mortality rates were seen due to subsequent malignancies (SMR = 19.4), along with cardiac (SMR = 8.2), pulmonary (SMR = 9.2), and other causes (SMR = 3.3). Treatment-related associations were present for subsequent cancer mortality (radiation, alkylating agents, epipodophyllotoxins), cardiac mortality (chest irradiation, bleomycin), and other deaths (radiation, anthracyclines). No excess mortality was observed for external causes (SMR = 0.8).

conclusionWhile recurrent disease remains a major contributor to late mortality in 5-year survivors of childhood cancer, significant excesses in mortality risk associated with treatment-related complications exist up to 25 years after the initial cancer diagnosis.

Indexed as

AdolescentAdultAge of OnsetAntineoplastic AgentsCause of DeathChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasmsRadiotherapyAntineoplastic Agents

Identifiers

PMID11432882
OpenAlexW1935834387

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.