ArticleThe EMBO journal2001
An upstream repressor element plays a role in Igf2 imprinting.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 94 citations in OpenAlex.
- Loss of keratin 14 expression from immortalized keratinocytes by promoter methylation.Experimental dermatology · 2024Article
- Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk.Human molecular genetics · 2019Article
- Review
- Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.Frontiers in psychiatry · 2019Review
- Epigenetics and developmental origins of diabetes: correlation or causation?American journal of physiology. Endocrinology and metabolism · 2018Review
- DNA methylation and its role in the pathogenesis of diabetes.Pediatric diabetes · 2017Review
- Perinatal high methyl donor alters gene expression in IGF system in male offspring without altering DNA methylation.Future science OA · 2017Article
- Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.European journal of nutrition · 2015Article
- Systematically Prioritizing Functional Differentially Methylated Regions (fDMRs) by Integrating Multi-omics Data in Colorectal Cancer.Scientific reports · 2015Article
- Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Human molecular genetics · 2014Article
- Paradoxical role of DNA methylation in activation of FoxA2 gene expression during endoderm development.The Journal of biological chemistry · 2014Article
- Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Review
- Choline nutrition programs brain development via DNA and histone methylation.Central nervous system agents in medicinal chemistry · 2012Review
- Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice.Endocrinology · 2012Article
- Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena.Genetics research international · 2012Article
- In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system.The European journal of neuroscience · 2011Review
- Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet.Alcohol (Fayetteville, N.Y.) · 2011Article
- Addition of H19 'loss of methylation testing' for Beckwith-Wiedemann syndrome (BWS) increases the diagnostic yield.The Journal of molecular diagnostics : JMD · 2010Article
- RNA-directed DNA methylation induces transcriptional activation in plants.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.Molecular endocrinology (Baltimore, Md.) · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.