ArticleThe Histochemical journal2001
Distinctive expression of extracellular matrix molecules at mRNA and protein levels during formation of cellular and acellular cementum in the rat.
Article in The Histochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface.Nature communications · 2026Article
- High-resolution multicontrast tomography with an X-ray microarray anode-structured target source.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effect of caspases and RANKL induced by heavy force in orthodontic root resorption.Korean journal of orthodontics · 2018Article
- Cementocyte cell death occurs in rat cellular cementum during orthodontic tooth movement.The Angle orthodontist · 2017Article
- Letter to the Editor, "Wnt Signaling and Its Contribution to Craniofacial Tissue Homeostasis".Journal of dental research · 2016Article
- Proteomic analysis of human dental cementum and alveolar bone.Journal of proteomics · 2013Article
- Imaging an adapted dentoalveolar complex.Anatomy research international · 2012Article
- Synthesis and intracellular transportation of type I procollagen during functional differentiation of odontoblasts.Histochemistry and cell biology · 2009Article
- Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections.Histochemistry and cell biology · 2007Article
- Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2005Article
- Expression of versican and ADAMTS during rat tooth eruption.Journal of molecular histology · 2005Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about differential expression of extracellular matrices secreted by cementoblasts between cellular and acellular cementum. We hypothesize that cementoblasts lining acellular cementum express extracellular matrix genes differently from those lining cellular cementum, thereby forming two distinct types of extracellular matrices. To test this hypothesis, we investigated spatial and temporal gene expression of selected extracellular matrix molecules, that is type I collagen, bone sialoprotein, osteocalcin and osteopontin, during formation of both cellular and acellular cementum using in situ hybridization. In addition, their extracellularly deposited and accumulated proteins were examined immunohistochemically. The mRNA transcripts of pro-alpha1 (I) collagen were primarily localized in cementoblasts of cellular cementum and cementocytes, while those of bone sialoprotein were predominantly seen in cementoblasts lining acellular cementum. In contrast, osteocalcin was expressed by both types of cementoblasts and cementocytes and so was osteopontin but only transiently. Our immunohistochemical examination revealed that translated proteins were localized extracellularly where the genes had been expressed intracellularly. The present study demonstrated the distinctive expression of genes and proteins of the extracellular matrix molecules between cellular and acellular cementum.
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