Trial reportBMJ (Clinical research ed.)2001
Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women.
Trial report in BMJ (Clinical research ed.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Cranberry-derived bioactives for the prevention and treatment of urinary tract infections: antimicrobial mechanisms and global research trends in nutraceutical applications.Frontiers in nutrition · 2025Pooled it
- Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2023Pooled it
- Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2023Pooled it
- Role of Probiotics for Recurrent UTIs in the Twenty-First Century: a Systematic Review of Literature.Current urology reports · 2022Pooled it
- Pooled it
- Increased fluid intake to prevent urinary tract infections: systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Pooled it
- Probiotics for preventing urinary tract infection in people with neuropathic bladder.The Cochrane database of systematic reviews · 2017Pooled it
- Cranberries and Urinary Tract Infections: How Can the Same Evidence Lead to Conflicting Advice?Advances in nutrition (Bethesda, Md.) · 2016Pooled it
- Probiotics for preventing urinary tract infections in adults and children.The Cochrane database of systematic reviews · 2015Pooled it
- Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2012Pooled it
- [Myth or truth. Cranberry juice for prophylaxis and treatment of recurrent urinary tract infection].Der Urologe. Ausg. A · 2009Pooled it
- Efficacy of D-mannose as prophylaxis of recurrent urinary tract infection: a systematic review and meta-analysis of randomized controlled trials.Jornal brasileiro de nefrologiaPooled it
- A Randomized Comparative Study of Luteolin-Based Herbal Unani FormulationsCurrent pharmaceutical design · 2025Trial
- A post-trial follow-up study of pentosan polysulfate monotherapy on preventing recurrent urinary tract infection in women.Scientific reports · 2022Trial
- Trial
- Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial.Journal of veterinary internal medicine · 2017Trial
- Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial.Clinical interventions in aging · 2017Trial
- Effect of oral cranberry extract (standardized proanthocyanidin-A) in patients with recurrent UTI by pathogenic E. coli: a randomized placebo-controlled clinical research study.International urology and nephrology · 2016Trial
- D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.World journal of urology · 2014Trial
- Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial.Mayo Clinic proceedings · 2012Trial
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether recurrences of urinary tract infection can be prevented with cranberry-lingonberry juice or with Lactobacillus GG drink.
designOpen, randomised controlled 12 month follow up trial.
settingHealth centres for university students and staff of university hospital.
participants150 women with urinary tract infection caused by Escherichia coli randomly allocated into three groups.
interventions50 ml of cranberry-lingonberry juice concentrate daily for six months or 100 ml of lactobacillus drink five days a week for one year, or no intervention.
main outcome measureFirst recurrence of symptomatic urinary tract infection, defined as bacterial growth >/=10(5 )colony forming units/ml in a clean voided midstream urine specimen.
resultsThe cumulative rate of first recurrence of urinary tract infection during the 12 month follow up differed significantly between the groups (P=0.048). At six months, eight (16%) women in the cranberry group, 19 (39%) in the lactobacillus group, and 18 (36%) in the control group had had at least one recurrence. This is a 20% reduction in absolute risk in the cranberry group compared with the control group (95% confidence interval 3% to 36%, P=0.023, number needed to treat=5, 95% confidence interval 3 to 34).
conclusionRegular drinking of cranberry juice but not lactobacillus seems to reduce the recurrence of urinary tract infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.