ArticleJournal of clinical pathology2001
Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitis.
Article in Journal of clinical pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis.BMC gastroenterology · 2017Pooled it
- Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.Carcinogenesis · 2015Pooled it
- Cellular crosstalk of fibroblast-myofibroblast transition in intestinal homeostasis and disease.Biomarker research · 2026Review
- Loss of mismatch repair promotes a direct selective advantage in human stem cells.Stem cell reports · 2022Article
- Article
- Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer.Journal for immunotherapy of cancer · 2020Review
- Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement.Clinical and translational gastroenterology · 2019Article
- Marine ω-3 polyunsaturated fatty acids and risk of colorectal cancer according to microsatellite instability.Journal of the National Cancer Institute · 2015Article
- Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease.World journal of gastroenterology · 2015Article
- Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis.World journal of gastroenterology · 2014Review
- Cancer in inflammatory bowel disease: lessons from animal models.Current opinion in gastroenterology · 2012Review
- Article
- Article
- Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice.Inflammatory bowel diseases · 2008Article
- Loss of fragile histidine triad protein expression in inflammatory bowel disease.World journal of gastroenterology · 2006Article
- IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.The Journal of experimental medicine · 2006Article
- A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.Cancer science · 2003Article
- The promoter methylation status of the DNA repair gene O6-methylguanine-DNA methyltransferase in ulcerative colitis.Virchows Archiv : an international journal of pathology · 2003Article
- Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral genetic alterations have been documented in dysplasia and cancer developing in ulcerative colitis (UC). However, the microsatellite instability (MSI) status has rarely been described, especially in the inflamed epithelium of UC.
aimsTo study MSI status during neoplastic and inflammatory changes in UC.
methodsSeventy five surgically resected samples of colorectal mucosa, taken from 16 colectomy specimens of patients with UC were examined: five patients had a long duration with dysplasia or cancer (UC-LD with neoplasm), seven patients had a long duration without neoplastic changes (UC-LD without neoplasm), and four patients had a short duration without neoplastic changes (UC-SD). In addition to MSI status examined by six microsatellite markers, p53 expression was compared among the three groups.
resultsWith regard to non-neoplastic inflamed epithelium, MSI in two or more loci (MSI> or =2) was seen more frequently in the UC-LD without neoplasm group than in the UC-SD group (six of 14 v one of 12; p = 0.060), and significantly more often than in the UC-LD with neoplasm group (six of 14 v two of 23; p = 0.016). In the UC-LD without neoplasm group, MSI> or =2 was detected significantly more frequently in patients with severe inflammation than in those with mild inflammation (six of nine v none of five; p = 0.028). With regard to neoplastic epithelium in the UC-LD with neoplasm group, MSI in two or more loci was found in three of 17, and p53 overexpression was seen in 11 of 17 of the neoplastic lesions.
conclusionsA high incidence of MSI in long standing UC with severe inflammation probably reflects genomic instability caused by repeated inflammatory stress. Thus, the influence of inflammation should be considered when estimating MSI in UC. It is possible that changes in p53 expression are important in the development of cancer in UC.
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