ArticleProceedings of the National Academy of Sciences of the United States of America2001
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 101 citations in OpenAlex.
- Trial
- A Self-Activating IL-15 Chimeric Cytokine Receptor to Empower Cancer Immunotherapy.ImmunoTargets and therapy · 2024Article
- Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.Trends in immunology · 2022Review
- Hmga2 deficiency is associated with allometric growth retardation, infertility, and behavioral abnormalities in mice.G3 (Bethesda, Md.) · 2022Article
- Critical role of the high mobility group A proteins in hematological malignancies.Hematological oncology · 2022Review
- Interplay between HMGA and TP53 in cell cycle control along tumor progression.Cellular and molecular life sciences : CMLS · 2021Review
- Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system.Frontiers of medicine · 2020Review
- HMGA Proteins in Hematological Malignancies.Cancers · 2020Review
- The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.International journal of molecular sciences · 2020Review
- HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas.International journal of molecular sciences · 2020Article
- Peptide Sequence Influence on the Conformational Dynamics and DNA binding of the Intrinsically Disordered AT-Hook 3 Peptide.Scientific reports · 2018Article
- Critical role of HMGA proteins in cancer cell chemoresistance.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.Pituitary · 2015Article
- Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.Oncotarget · 2015Article
- Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas.Frontiers in medicine · 2015Review
- Increased serum levels of interleukin-15 correlate with negative prognostic factors in extranodal NK/T cell lymphoma.Medical oncology (Northwood, London, England) · 2015Article
- High mobility group a proteins as tumor markers.Frontiers in medicine · 2015Review
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemia.Blood cancer journal · 2014Article
- HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that HMGI-C/T TG mice develop natural killer (NK)-T/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C/T protein positively regulates their expression in vitro. Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.