ArticleProceedings of the National Academy of Sciences of the United States of America2001
Neurotensin-deficient mice show altered responses to antipsychotic drugs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome.Frontiers of medicine · 2025Article
- Neurotensin differentially regulates bile acid metabolism and intestinal FXR-bile acid transporter axis in response to nutrient abundance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Article
- Striatal dopamine receptor plasticity in neurotensin deficient mice.Behavioural brain research · 2015Article
- Repeated effects of the neurotensin receptor agonist PD149163 in three animal tests of antipsychotic activity: assessing for tolerance and cross-tolerance to clozapine.Pharmacology, biochemistry, and behavior · 2015Article
- Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.PloS one · 2014Article
- Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.Psychopharmacology · 2012Article
- Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.Neuropharmacology · 2010Article
- Article
- Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.Nature medicine · 2008Article
- Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.Neuropharmacology · 2008Article
- Hormonal regulation of clonal, immortalized hypothalamic neurons expressing neuropeptides involved in reproduction and feeding.Molecular neurobiology · 2007Article
- Medical sequencing at the extremes of human body mass.American journal of human genetics · 2007Article
- Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Anorexigenic hormones leptin, insulin, and alpha-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The peptide transmitter neurotensin (NT) exerts diverse neurochemical effects that resemble those seen after acute administration of antipsychotic drugs (APDs). These drugs also induce NT expression in the striatum; this and other convergent findings have led to the suggestion that NT may mediate some APD effects. Here, we demonstrate that the ability of the typical APD haloperidol to induce Fos expression in the dorsolateral striatum is markedly attenuated in NT-null mutant mice. The induction of Fos and NT in the dorsolateral striatum in response to typical, but not atypical, APDs has led to the hypothesis that the increased expression of these proteins is mechanistically related to the production of extrapyramidal side effects (EPS). However, we found that catalepsy, which is thought to reflect the EPS of typical APDs, is unaffected in NT-null mutant mice, suggesting that NT does not contribute to the generation of EPS. We conclude that NT is required for haloperidol-elicited activation of a specific population of striatal neurons but not haloperidol-induced catalepsy. These results are consistent with the hypothesis that endogenous NT mediates a specific subset of APD actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.