ArticleClinical and diagnostic laboratory immunology2001
Comparison of hepatitis C viral loads in patients with or without human immunodeficiency virus.
Article in Clinical and diagnostic laboratory immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2007Trial
- Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients.Gastroenterology · 2005Trial
- HCV-specific CD4EBioMedicine · 2026Article
- Article
- Exploring Awareness of HCV Among Sexual-Minority Black Generation Millennials and Gen Z: a Qualitative Study.Journal of racial and ethnic health disparities · 2020Article
- Deriving the optimal limit of detection for an HCV point-of-care test for viraemic infection: Analysis of a global dataset.Journal of hepatology · 2019Article
- Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users.Virology journal · 2017Article
- Virologic and immunologic aspects of HIV-hepatitis C virus coinfection.AIDS (London, England) · 2016Review
- Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.PLoS pathogens · 2015Article
- HIV Vpr protein upregulates microRNA-122 expression and stimulates hepatitis C virus replication.The Journal of general virology · 2015Article
- The "hidden" epidemic: a snapshot of Moroccan intravenous drug users.Virology journal · 2014Article
- Article
- Acute hepatitis C in an HIV-infected patient: a case report and review of literature.Journal of general internal medicine · 2013Review
- Effect of HIV on liver fibrosis among HCV-infected African Americans.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Substance abuse, HIV-1 and hepatitis.Current HIV research · 2012Review
- Plasma Hepatitis C Virus Viral Load Among Hepatitis C Virus Mono-Infected and HCV/HIV Co-Infected Individuals in Yunnan Province,China.Hepatitis monthly · 2012Article
- Recent hepatitis C virus infections in HIV-infected patients in Taiwan: incidence and risk factors.Journal of clinical microbiology · 2012Article
- Opioids and HIV/HCV infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
- Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report.Journal of medical case reports · 2011Article
- Acute hepatitis C in persons infected with the human immunodeficiency virus (HIV): the "real-life setting" proves the concept.European journal of medical research · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
A better understanding of how human immunodeficiency virus (HIV) coinfection affects the course of hepatitis C virus (HCV) infection is required to select patients with HIV who would benefit from current HCV therapy. Between June 1996 and March 2000, HCV RNA levels were quantified for 1,279 patients at the Louisiana State University Health Sciences Center; 28 of these patients were coinfected with HIV. HCV loads were quantified by the Bayer branched-DNA assay with a lower limit of detection of 0.2 Meq/ml. We compared the median HCV RNA levels of for patients coinfected with HIV and HCV and patients infected only with HCV who were in the same age range (23 to 55 years). The median HCV load for the 28 patients coinfected with HCV and HIV (17.8 Meq/ml) was significantly greater (P < 0.05) than that for similarly aged patients infected only with HCV (6.1 Meq/ml). The HCV load did not correlate with age or sex for either group of patients. A significant (R = -0.4; P < 0.05) negative correlation was observed between HCV load and CD4 count in the coinfected group, for whom the CD4 counts at the time of HCV load analysis ranged from 6 to 1,773/mm(3). The increased HCV load in patients coinfected with HCV and HIV compared to that in patients infected only with HCV and the inverse relationship of the HCV load to the CD4 count indicate that immunosuppression results in decreased control of HCV replication. In addition, we report significantly higher HCV loads among coinfected African Americans than Caucasians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.