ArticleInternational journal of impotence research2001
Effects of diabetes on neurotransmission in rat vaginal smooth muscle.
Article in International journal of impotence research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 66 citations in OpenAlex.
- Therapeutic Potential of Bone Marrow- and Ovarian/Endometrium-Derived Mesenchymal Stem Cells in Regulating Ovarian Function in a Streptozotocin-Induced Diabetes Mellitus Rat Model.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Addressing Sexual Dysfunction in Women With Type 1 Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2025Review
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- Mechanosensitive Vaginal Epithelial Adenosine Triphosphate Release and Pannexin 1 Channels in Healthy, in Type 1 Diabetic, and in Surgically Castrated Female Mice.The journal of sexual medicine · 2020Article
- Nerve-induced responses of mouse vaginal smooth muscle.Pflugers Archiv : European journal of physiology · 2017Article
- Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity.Autonomic neuroscience : basic & clinical · 2015Review
- Frequency of sexual dysfunction and its causative factors among diabetic women in Turkey.Pakistan journal of medical sciences · 2014Article
- Diabetes and sexual dysfunction: current perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
- Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats.Cellular and molecular neurobiology · 2012Article
- Characterization of the vasculature supplying the genital tissues in female rats.The journal of sexual medicine · 2012Article
- Adaptive plasticity of vaginal innervation in term pregnant rats.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Internal pudendal artery from type 2 diabetic female rats demonstrate elevated endothelin-1-mediated constriction.The journal of sexual medicine · 2011Article
- Functional significance of muscarinic receptor expression within the proximal and distal rat vagina.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Female sexual dysfunction: therapeutic options and experimental challenges.Cardiovascular & hematological agents in medicinal chemistry · 2009Review
- Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers.BMC physiology · 2006Article
- Article
- Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility.International journal of impotence research · 2004Article
- Androgen therapy with dehydroepiandrosterone.World journal of urology · 2003Review
- Histological and functional aspects of different regions of the rabbit vagina.International journal of impotence research · 2003Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the animals were killed, the distal part of the vagina was removed, and smooth muscle strips were prepared for functional organ bath experiments and for measurement of nitric oxide synthase (NOS) activity. In DM preparations, the EC(50) value for noradrenaline (NA) was significantly increased (P<0.05) and the maximal contractile response decreased (P=0.001). In preparations precontracted with NA, the NO donor SNAP and calcitonin gene-related peptide (CGRP) caused concentration-dependent relaxations, which were significantly decreased (P<0.001) in the DM group. Electrical stimulation of nerves (EFS) caused frequency-dependent contractions, which were significantly lower in DM than in NDM strips (P<0.001). SNAP and CGRP concentration-dependently inhibited EFS evoked contractions in both NDM and DM preparations. The inhibition was significantly lower (P<0.05) in the DM group. In NDM preparations precontracted with NA, EFS evoked frequency-dependent relaxations; such relaxations were inhibited or reduced in DM. Treatment with the NOS inhibitor, L-NOARG 0.1 mM, abolished relaxations in all preparations or produced contraction in DM preparations. Calcium-dependent NOS activity was not significantly different in the DM and NDM groups. However, the DM animals showed a small but significant increase in calcium-independent NOS-activity (P<0.05). Diabetes interferes with adrenergic-, cholinergic- and NANC-neurotransmitter mechanisms in the smooth muscle of the rat vagina. The changes in the nitrergic neurotransmission are not due to reduction in NOS-activity, but seem to be due to interference with later steps in the L-arginine/NO/guanylate cyclase/cGMP system.
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