ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 111 citations in OpenAlex.
- Changes in Palatability Processing across the Estrous Cycle Are Modulated by Hypothalamic Estradiol Signaling.eNeuro · 2026Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Chemosensory epithelial cells in the urethra: sentinels of the urinary tract.Histochemistry and cell biology · 2016Review
- Breadth of tuning in taste afferent neurons varies with stimulus strength.Nature communications · 2015Article
- L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors.PloS one · 2015Article
- Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directions.Frontiers in molecular neuroscience · 2014Review
- A gustotopic map of taste qualities in the mammalian brain.Science (New York, N.Y.) · 2011Article
- Citric acid and quinine share perceived chemosensory features making oral discrimination difficult in C57BL/6J mice.Chemical senses · 2011Article
- The cell biology of taste.The Journal of cell biology · 2010Review
- Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells.The Journal of physiology · 2010Article
- Coding in the mammalian gustatory system.Trends in neurosciences · 2010Review
- ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampus.Molecular and cellular biochemistry · 2010Review
- Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells.The Journal of physiology · 2009Article
- Voltage-gated sodium channels in taste bud cells.BMC neuroscience · 2009Article
- Molecular mechanisms of taste transduction in vertebrates.Odontology · 2009Review
- Breadth of tuning and taste coding in mammalian taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The neural processing of taste.BMC neuroscience · 2007Review
- Signal transduction and information processing in mammalian taste buds.Pflugers Archiv : European journal of physiology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Several taste transduction mechanisms have been demonstrated in mammals, but little is known about their distribution within and across receptor cells. We recorded whole-cell responses of 120 taste cells of the rat fungiform papillae and soft palate maintained within the intact epithelium in a modified Ussing chamber, which allowed us to flow tastants across the apical membrane while monitoring the activity of the cell with a patch pipette. Taste stimuli were: 0.1 m sucrose, KCl, and NH(4)Cl, 0.032 m NaCl, and 3.2 mm HCl and quinine hydrochloride (QHCl). When cells were held at their resting potentials, taste stimulation resulted in conductance changes; reversible currents >5 pA were considered reliable responses. Sucrose and QHCl produced a decrease in outward current and membrane conductance, whereas NaCl, KCl, NH(4)Cl, and HCl elicited inward currents accompanied by increased conductance. Combinations of responses to pairs of the four basic stimuli (sucrose, NaCl, HCl, and QHCl) across the 71-84 cells tested with each pair were predictable from the probabilities of responses to individual stimuli, indicating an independent distribution of sensitivities. Of 62 cells tested with all four basic stimuli, 59 responded to at least one of the stimuli; 16 of these (27.1%) responded to only one, 20 (33.9%) to two, 15 (25.4%) to three, and 8 (13.6%) to all of the basic stimuli. Cells with both inward (Na(+)) and outward (K(+)) voltage-activated currents were significantly more broadly tuned to gustatory stimuli than those with only inward currents.
Indexed as
Identifiers
11425921PMC6762376W1956714534What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.