ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 143 citations in OpenAlex.
- Review
- The distinct localization of CDC42 isoforms is responsible for their specific functions during migration.The Journal of cell biology · 2024Article
- The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells.BMC oral health · 2024Article
- Type III NRG-1 plays a regulatory role in the regeneration process of nerves from the beginning of transplantation.Journal of orthopaedic surgery and research · 2023Article
- Two different isoforms of osteopontin modulate myelination and axonal integrity.FASEB bioAdvances · 2023Article
- Review
- Effect of neuregulin-1 on the auditory cortex in adult C57BL/6J mice.Iranian journal of basic medical sciences · 2020Article
- The role of oligodendrocytes and their progenitors on neural interface technology: A novel perspective on tissue regeneration and repair.Biomaterials · 2018Review
- Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis.Frontiers in genetics · 2018Article
- Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network.European archives of psychiatry and clinical neuroscience · 2017Article
- Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury.The Journal of physiology · 2016Review
- Discovery of Novel Biomarkers for Alzheimer's Disease from Blood.Disease markers · 2016Article
- Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration.Frontiers in molecular neuroscience · 2016Review
- Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases.Frontiers in neuroscience · 2015Article
- Change of fate commitment in adult neural progenitor cells subjected to chronic inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase.ASN neuro · 2014Article
- NF-κB signaling regulates myelination in the CNS.Frontiers in molecular neuroscience · 2014Review
- Human embryonic stem cell-derived oligodendrocytes: protocols and perspectives.Stem cells and development · 2013Review
- Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway.Psychopharmacology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuregulin 1 (Nrg-1) isoforms have been shown to influence the emergence and growth of oligodendrocytes, the CNS myelin-forming cells. We have investigated how Nrg-1 signaling of ErbB receptors specifically controls the early stages of oligodendrocyte generation from multipotential neural precursors (NPs). We show here that embryonic striatal NPs express multiple Nrg-1 transcripts and proteins as well as their specific receptors, ErbB2 and ErbB4, but not ErbB3. The major isoform synthesized by striatal NPs is a transmembrane type III isoform called cysteine-rich domain Nrg-1. To examine the biological effect of Nrg-1, we added soluble ErbB3 (sErbB3) to growing neurospheres. This inhibitor of Nrg-1 bioactivity decreased mitosis of NPs and increased their apoptosis, resulting in a significant reduction in neurosphere size and number. When NPs were induced to migrate and differentiate by adhesion of neurospheres to the substratum, the level of type III isoforms detected by RT-PCR and Western blot decreased in parallel with a reduction in Nrg-1 fluorescence intensity in differentiating astrocytes, neurons, and oligodendrocytes. Pretreatment of growing neurospheres with sErbB3 induced a threefold increase in the proportion of oligodendrocytes generated from NPs migrating out of the neurosphere. This effect was not observed with an unrelated soluble receptor. Addition of sErbB3 during NP growth and differentiation enhanced oligodendrocyte maturation as shown by expression of galactocerebroside and myelin basic protein. We propose that both type III Nrg-1 signaling and soluble ErbB receptors modulate oligodendrocyte development from NPs.
Indexed as
Identifiers
11425901PMC6762347W2157007804What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.