ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
NMDA receptor and nitric oxide synthase activation regulate polysialylated neural cell adhesion molecule expression in adult brainstem synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Region-Specific Adult Neural Stem Cell Niches of the Mediobasal Hypothalamus and Medulla Oblongata.Stem cell reviews and reports · 2026Review
- Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception.International journal of molecular sciences · 2022Review
- Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression.Behavioural brain research · 2019Article
- Polysialic Acid Regulates Sympathetic Outflow by Facilitating Information Transfer within the Nucleus of the Solitary Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Acupuncture and regulation of gastrointestinal function.World journal of gastroenterology · 2015Review
- A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats.Neuropharmacology · 2014Article
- Oculomotor nerve injury induces nuerogenesis in the oculomotor and Edinger-Westphal nucleus of adult dog.Journal of molecular neuroscience : MN · 2013Article
- Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.Scientific reports · 2013Article
- Article
- Alteration of forebrain neurogenesis after cervical spinal cord injury in the adult rat.Frontiers in neuroscience · 2012Article
- Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The CNS synapse revisited: gaps, adhesive welds, and borders.Neurochemical research · 2007Review
- Neurobiological and endocrine correlates of individual differences in spatial learning ability.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report that synapses in the adult dorsal vagal complex, a gateway for many primary afferent fibers, express a high level of the polysialylated neural cell adhesion molecule (PSA-NCAM). We show that electrical stimulation of the vagal afferents causes a rapid decrease of PSA-NCAM expression both in vivo and in acute slices. Inhibition of NMDA receptor activity completely prevented the decrease. Blockade of calmodulin activation, neuronal nitric oxide (NO) synthase, or soluble guanylyl cyclase and chelation of extracellular NO mimicked this inhibition. Our data provide a mechanistic framework for understanding how activity-linked stimulation of the NMDA-NO-cGMP pathway induces rapid changes in PSA-NCAM expression, which may be associated with long-term depression.
Indexed as
Identifiers
11425899PMC6762337W1903787762What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.