ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
The OMP-lacZ transgene mimics the unusual expression pattern of OR-Z6, a new odorant receptor gene on mouse chromosome 6: implication for locus-dependent gene expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- A purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers.BMC bioinformatics · 2019Article
- Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.Nature communications · 2018Article
- A Near-Complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium.Chemical senses · 2018Article
- Histone and DNA Modifications as Regulators of Neuronal Development and Function.Cold Spring Harbor perspectives in biology · 2016Review
- The Mouse Solitary Odorant Receptor Gene Promoters as Models for the Study of Odorant Receptor Gene Choice.PloS one · 2016Article
- Monoallelic expression of olfactory receptors.Annual review of cell and developmental biology · 2015Review
- Article
- Odorant receptor (OR) gene choice is biased and non-clonal in two olfactory placode cell lines, and OR RNA is nuclear prior to differentiation of these lines.Journal of neurochemistry · 2009Article
- Mammalian olfactory receptors.Frontiers in cellular neuroscience · 2009Article
- Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes.BMC neuroscience · 2007Review
- High-throughput microarray detection of olfactory receptor gene expression in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.Genome biology · 2003Article
- Specificity of glomerular targeting by olfactory sensory axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Reporter gene expression in the olfactory epithelium of H-lacZ6 transgenic mice mimics the cell-selective expression pattern known for some odorant receptor genes. The transgene construct in these mice consists of the lacZ coding region, driven by the proximal olfactory marker protein (OMP) gene promoter, and shows expression in a zonally confined subpopulation of olfactory neurons. To address mechanisms underlying the odorant receptor-like expression pattern of the lacZ construct, we analyzed the transgene-flanking region and identified OR-Z6, the first cloned odorant receptor gene that maps to mouse chromosome 6. OR-Z6 bears the highest sequence similarity (85%) to a human odorant receptor gene at the syntenic location on human chromosome 7. We analyzed the expression pattern of OR-Z6 in olfactory tissues of H-lacZ6 mice and show that it bears strong similarities to that mapped for beta-galactosidase. Expression of both genes in olfactory neurons is primarily restricted to the same medial subregion of the olfactory epithelium. Axons from both neuronal subpopulations project to the same ventromedial aspect of the anterior olfactory bulbs. Furthermore, colocalization analyses in H-lacZ6 mice demonstrate that OR-Z6-reactive glomeruli receive axonal input from lacZ-positive neurons as well. These results suggest that the expression of both genes is coordinated and that transgene expression in H-lacZ6 mice is regulated by locus-dependent mechanisms.
Indexed as
Identifiers
11425891PMC6762339W2149459712What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.