Evidence map›Paper›PMID 11425890›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001

Pituitary adenylyl cyclase-activating peptides and alpha-amidation in olfactory neurogenesis and neuronal survival in vitro.

D E Hansel, V May, B A Eipper, G V Ronnett

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The molecular mechanisms of copper metabolism and its roles in human diseases.Pflugers Archiv : European journal of physiology · 2020
    Review
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Article
  11. Peripheral modulation of smell: fact or fiction?Seminars in cell & developmental biology · 2013
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004
    Article
  19. Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

D E HanselDepartment of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
V May
B A Eipper
G V Ronnett
Johns Hopkins Medicine · USUConn Health · USUniversity of Vermont · US

Funding

UNDERSTANDING NO SIGNALING RESULTING IN NEUROPROTECTION.P50DA000266 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 1985 to 2017
$45.2M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR01DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, KING, STEPHEN M · 1986 to 2017
$6.4M
REGULATION OF GUANYLYL CYCLASES IN THE OLFACTORY SYSTEMR01DC002979 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI RONNETT, GABRIELE V · 1997 to 2012
$4.2M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR37DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 1989 to 2004
$2.8M
REGULATION OF PEPTIDE EXPRESSION IN NEURONAL CELLSR01HD027468 · NICHD · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI MAY, VICTOR · 1991 to 2005
$1.8M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR56DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 2005 to 2005
$104k
NICHD NIH HHS HD-27468NICHD NIH HHS R01 HD027468NIDA NIH HHS DA-00266NIDA NIH HHS P50 DA000266NIDCD NIH HHS DC-2979NIDCD NIH HHS R01 DC002979NIDDK NIH HHS DK-32949NIDDK NIH HHS R01 DK032949NIDDK NIH HHS R37 DK032949NIDDK NIH HHS R56 DK032949
6 · The paper itself

Abstract

We investigated the role of amidated neuropeptides, and specifically pituitary adenylyl cyclase-activating polypeptide (PACAP), in olfactory neurogenesis and olfactory receptor neuronal survival. Using both immunohistochemistry and in situ hybridization, we find that both peptidylglycine alpha-amidating monooxygenase (PAM), the enzyme responsible for amidation and therefore activation of all amidated neuropeptides, and amidated PACAP are expressed in developing and adult olfactory epithelium. Amidated PACAP is highly expressed in proliferative basal cells and in immature olfactory neurons. The PACAP-specific receptor PAC(1) receptor is also expressed in this population, establishing that these cells can be PACAP responsive. Experiments were conducted to determine whether amidated neuropeptides, such as PACAP38, might function in olfactory neurogenesis and neuronal survival. Addition of PACAP38 to olfactory cultures increased the number of neurons to >250% of control and stimulated neuronal proliferation and survival. In primary olfactory cultures, pharmacologically decreased PAM activity, as well as neutralization of PACAP38, caused neuron-specific loss that was reversed by PACAP38. Mottled (Brindled) mice, which lack a functional ATP7A copper transporter and serve as a model for Menkes disease, provided an in vivo partial loss-of-function PAM knock-out. These mice had decreased amidated PACAP production and concomitant decreased numbers of olfactory receptor neurons. These data establish amidated peptides and specifically PACAP as having important roles in proliferation in the olfactory system and suggest that a similar function exists in vivo.

Indexed as

Cation Transport ProteinsMultienzyme ComplexesRecombinant Fusion ProteinsAdenosine TriphosphatasesAgingAmidesAnimalsCarrier ProteinsCell CountCell DivisionCell SurvivalCopper-Transporting ATPasesDitiocarbDose-Response Relationship, DrugFemaleIn Situ HybridizationAdcyap1 protein, mouseAdcyap1 protein, ratAdenosine TriphosphatasesAmidesAtp7a protein, mouseAtp7a protein, ratCarrier ProteinsCation Transport ProteinsCopper-Transporting ATPasesDitiocarbMixed Function OxygenasesMultienzyme ComplexesNeuropeptidesPeptide Fragmentspeptidylglycine monooxygenasepituitary adenylate-cyclase-activating-peptide (6-38)Pituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary HormoneRecombinant Fusion Proteins

Identifiers

PMID11425890
PMCPMC6762377
OpenAlexW2147074244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.