ArticleGlycoconjugate journal2000
Sialyl-Le(x) and sulfo-sialyl-Le(x) determinants are receptors for P. aeruginosa.
Article in Glycoconjugate journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Immunoglobulin A carries sulfated andFrontiers in molecular biosciences · 2025Article
- Insights onMicroorganisms · 2024Article
- Identification and characterization of sulfated carbohydrate-binding protein from Lactobacillus reuteri.PloS one · 2013Article
- A single step method for purification of sulfated oligosaccharides.Glycoconjugate journal · 2008Article
- Control of core 2 beta1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells.Glycoconjugate journal · 2007Article
- Pseudomonas aeruginosa mucoid strain 8830 binds glycans containing the sialyl-Lewis x epitope.Glycoconjugate journal · 2007Article
- Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.The Biochemical journal · 2005Article
- Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma.The American journal of pathology · 2005Article
- Recognition of Lewis x derivatives present on mucins by flagellar components of Pseudomonas aeruginosa.Infection and immunity · 2001Article
- Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis.Glycoconjugate journal · 2001Review
- Influence of TNFalpha on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells.Glycoconjugate journal · 2001Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa, the main pathogen in the airways of patients suffering from cystic fibrosis (CF), binds to carbohydrate chains of respiratory mucins. Using flow cytometry and polyacrylamide based fluorescent glycoconjugates, it was previously demonstrated that several strains of P. aeruginosa recognize a set of neutral and acidic carbohydrate epitopes found at the periphery of respiratory mucins, especially sialyl-Le(x). This structure, overexpressed in mucins from CF patients, could be responsible in part for the persistence of lung infection in CF patients. The aim of the present work was to determine whether a glycoconjugate bearing the 6-sulfo-sialyl-Le(x) epitope, also found in abundance in CF airway mucins, is also preferentially recognised by different strains of P. aeruginosa. The study was conducted with a nonpiliated strain 1244-NP and four mucoid strains isolated from CF patients. For four strains out of five, the affinity for 6-sulfo-sialyl-Le(x) was as high as for sialyl-Le(x) derivative. These results were confirmed for strain 1244-NP by a microtiter plate assay.
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