ArticleThe British journal of ophthalmology2001
Human papillomavirus in pterygium.
Article in The British journal of ophthalmology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 99 citations in OpenAlex.
- Triple subconjunctival bevacizumab injection for early corneal recurrent pterygium: one-year follow-up.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Trial
- The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.International ophthalmology · 2023Article
- Article
- Evaluation of Primary Pterygia on Basis of the Loss of Vertical Length of Plica Semilunaris.Translational vision science & technology · 2021Article
- Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye.Scientific reports · 2021Observational
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- Pterygium concomitant with other ocular surface lesions: Clinical implications and pathogenetic links.Experimental and therapeutic medicine · 2016Article
- human adenoviruses role in ophthalmic pterygium formation.Jundishapur journal of microbiology · 2015Article
- Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review).International journal of molecular medicine · 2013Review
- Lymphatic microvessel density as a predictive marker for the recurrence time of pterygium: a three-year follow-up study.Molecular vision · 2013Article
- New approach for pterygium removal using 20 % ethanol.International ophthalmology · 2012Article
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.Eye (London, England) · 2012Review
- Analysis of pathohistological characteristics of pterygium.Bosnian journal of basic medical sciences · 2010Article
- Human papillomavirus infection and squamous cell carcinoma of the conjunctiva.British journal of cancer · 2010Article
- HPV infection and p53 inactivation in pterygium.Molecular vision · 2009Article
- Expression of survivin protein in pterygium and relationship with oxidative DNA damage.Journal of cellular and molecular medicine · 2008Article
- Human papillomavirus and pterygium. Is the virus a risk factor?The British journal of ophthalmology · 2007Article
- Intraoperative ethanol treatment as an adjuvant therapy of pterygium excision.International journal of biomedical science : IJBS · 2006Article
- Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation.The American journal of pathology · 2005Article
- Lack of human papillomavirus in pterygium of Chinese patients from Taiwan.The British journal of ophthalmology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the prevalence and significance of human papillomaviral types in conjunctival pterygia.
methodsPolymerase chain reaction technology was used to identify the presence of human papillomavirus (HPV) in 10 formalin fixed paraffin embedded pterygia samples. 10 conjunctival papillomas were used as positive controls. 20 conjunctival samples, 10 with primary acquired melanosis and 10 with malignant melanoma, were used as negative controls. Sample subgroups were of equal sex, race, and age distribution to eliminate bias. All samples were further analysed (for 21 HPV types) using dot-blot hybridisation techniques.
resultsHPV was identified in 90% of the conjunctival papillomas, 50% of the pterygia samples, but no HPV was detected in the negative control group. Two pterygia showed type 6, two type 11, and one type 16. These three HPV types were also detected in papillomas.
conclusionThese results suggest that HPV may be involved in the pathogenesis of pterygia and that broadly the same HPV types are found in pterygia and in papillomas. Persistent conjunctival HPV may possibly play a part in the recurrence of pterygia post excision but further larger studies are required to elucidate this hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.