ArticleBiophysical journal2001
Vesicle trafficking and cell surface membrane patchiness.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response.Biophysical journal · 2015Article
- Sensing Size through Clustering in Non-Equilibrium Membranes and the Control of Membrane-Bound Enzymatic Reactions.PloS one · 2015Article
- Plasma membrane organization and function: moving past lipid rafts.Molecular biology of the cell · 2013Article
- Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton.Biophysical journal · 2012Article
- HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.The Journal of biological chemistry · 2010Article
- Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses.Immunologic research · 2010Review
- Measuring rotational diffusion of MHC class I on live cells by polarized FPR.Biophysical chemistry · 2007Article
- Dynamic patches of membrane proteins.Biophysical journal · 2007Article
- Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Dynamics in the plasma membrane: how to combine fluidity and order.The EMBO journal · 2006Review
- Article
- Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model.Proceedings of the National Academy of Sciences of the United States of America · 2003Review
- Confocal FRET microscopy to measure clustering of ligand-receptor complexes in endocytic membranes.Biophysical journal · 2003Article
- The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages.The Journal of membrane biology · 2003Article
- Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts.Biophysical journal · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Membrane proteins and lipids often appear to be distributed in patches on the cell surface. These patches are often assumed to be membrane domains, arising from specific molecular associations. However, a computer simulation (Gheber and Edidin, 1999) shows that membrane patchiness may result from a combination of vesicle trafficking and dynamic barriers to lateral mobility. The simulation predicts that the steady-state patches of proteins and lipids seen on the cell surface will decay if vesicle trafficking is inhibited. To test this prediction, we compared the apparent sizes and intensities of patches of class I HLA molecules, integral membrane proteins, before and after inhibiting endocytic vesicle traffic from the cell surface, either by incubation in hypertonic medium or by expression of a dominant-negative mutant dynamin. As predicted by the simulation, the apparent sizes of HLA patches increased, whereas their intensities decreased after endocytosis and vesicle trafficking were inhibited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.