ArticleHearing research2001
Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice.
Article in Hearing research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- CaProceedings of the National Academy of Sciences of the United States of America · 2026Article
- An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice.Neural plasticity · 2020Article
- Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice.Scientific reports · 2019Article
- The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.Hearing research · 2018Article
- Article
- Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.Scientific reports · 2017Article
- Anti-apoptotic treatment in mouse models of age-related hearing loss.Journal of otology · 2016Review
- Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test.Journal of visualized experiments : JoVE · 2015Article
- Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.Neuroscience letters · 2014Article
- A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.Hearing research · 2013Article
- Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Alleles that modulate late life hearing in genetically heterogeneous mice.Neurobiology of aging · 2012Article
- A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.Gene · 2012Article
- A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs.The pharmacogenomics journal · 2012Article
- Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice.Neurotoxicity research · 2011Article
- A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice.Neurobiology of aging · 2009Article
- Mouse models for human otitis media.Brain research · 2009Review
- Inheritance patterns of progressive hearing loss in laboratory strains of mice.Brain research · 2009Review
- The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.Neurobiology of aging · 2008Article
- Tympanometry assessment of 61 inbred strains of mice.Hearing research · 2007Article
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2 authors at 1 institution in 1 country.
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Abstract
The modifier of deaf waddler (mdfw) and age-related hearing loss (Ahl) loci were both discovered as inbred strain polymorphisms that affect hearing loss in mice. Both loci map to the same position on chromosome (Chr) 10. The mdfw locus interacts epistatically with the deaf waddler (dfw) mutation on Chr 6, and the Ahl locus is a major contributor to AHL in several inbred strains. To investigate the possibility of allelism, we examined the correspondence of mdfw and Ahl phenotypes among 12 inbred mouse strains. The effects of strain-specific mdfw alleles on hearing loss were assessed in dfw2J/+ F1 hybrids produced from mating BALB-dfw2J/+ mice with mice from each of 12 inbred strains. F1 hybrids were then assessed for hearing by auditory-evoked brainstem response threshold analysis and classified as dfw2J/+ or +/+ by polymerase chain reaction typing. Heterozygosity for dfw2J accelerated hearing loss in F1 hybrids derived from all strains tested, except those produced with the B6.CAST + Ahl congenic strain. dfw2J/+ F1 hybrids derived from parental strains 129P1/ReJ, A/J, BUB/BnJ, C57BR/cdJ, DBA/2J, NOD/LtJ and SKH2/J exhibited a severe hearing loss by 12 weeks of age. Those derived from strains 129T2/SvEmsJ, C3H/HeJ, CBA/CaJ and NON/LtJ exhibited only a slight to intermediate hearing loss at that age. The hearing loss associated with these strain-specific mdfw alleles corresponds with previously determined Ahl allele effects, providing additional evidence that mdfw and Ahl are manifestations of the same gene. A functional relationship therefore may exist between the Ca2+ transporting activity of the dfw gene (Atp2b2) and AHL.
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