ArticleKidney international2001
Role of glucocorticoids in the maturation of the rat renal Na+/H+ antiporter (NHE3).
Article in Kidney international, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- The Role of Renal Na+/H+ Exchange in the Regulation of Acid-Base and Sodium Homeostasis in Premature Infants.Physiological research · 2026Review
- Developmental changes in renal tubular transport-an overview.Pediatric nephrology (Berlin, Germany) · 2015Review
- Glucocorticoids Reduce Renal NHE8 Expression.Physiological reports · 2013Article
- Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Effect of metabolic acidosis on neonatal proximal tubule acidification.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.American journal of physiology. Renal physiology · 2009Article
- Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Developmental changes in proximal tubule NaCl transport.Pediatric nephrology (Berlin, Germany) · 2008Review
- Ontogeny of NHE8 in the rat proximal tubule.American journal of physiology. Renal physiology · 2007Article
- Cortisol increases the activities of intestinal apical membrane hydrolases and nutrient transporters before weaning in mink (Mustela vison).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2006Article
- Fibroblast growth factor-23 increases mouse PGE2 production in vivo and in vitro.American journal of physiology. Renal physiology · 2006Article
- Maturation of rat proximal tubule chloride permeability.American journal of physiology. Regulatory, integrative and comparative physiology · 2005Article
- Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.American journal of physiology. Renal physiology · 2005Article
- Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation.American journal of physiology. Renal physiology · 2005Article
- Maturation of the Na+/H+ antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalectomized rat.American journal of physiology. Renal physiology · 2004Article
- Ontogeny of water transport in the rabbit proximal tubule.Pediatric nephrology (Berlin, Germany) · 2003Review
- Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Effect of prenatal corticosteroids on the maturation of renal tubules in preterm infants.Jornal brasileiro de nefrologiaArticle
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeonates have a lower Na+/H+ antiporter activity on the apical membrane of proximal tubule than that of adults. The maturational increase in Na+/H+ antiporter activity occurs at the time when there is a rise in serum glucocorticoid levels in rats. The purpose of the present study was to examine whether glucocorticoids are responsible for the postnatal increase in Na+/H+ antiporter activity.
methodsNine-day-old Sprague-Dawley rats were compared with rats studied at 30 days of age who had either a sham operation or adrenalectomy (ADX) at nine days of age and with rats that had an adrenalectomy and physiologic corticosterone replacement (ADX-Cort) to determine whether glucocorticoid deficiency prevented the maturational increase in Na+/H+ antiporter activity. Na+/H+ antiporter activity was measured in proximal convoluted tubules perfused in vitro by the change in cell pH (pHi) following luminal sodium removal. NHE3 mRNA abundance was measured using Northern blot analysis, and NHE3 protein abundance was measured by immunoblot.
resultsNa+/H+ antiporter activity was 93.8 +/- 17.7, 157.0 +/- 18.0, 356.7 +/- 29.9, and 402.5 +/- 14.5 pmol/mm. min in nine-day-old, ADX, ADX-Cort, and sham control groups, respectively. The ADX-Cort and sham control were higher than the 9-day-old and the 30-day-old ADX group (P < 0.05). Brush-border membrane NHE3 protein abundance in the nine-day-old and ADX groups were sixfold less than ADX-Cort and sham control groups (P < 0.001). Nine-day-old neonates had fivefold less renal cortical NHE3 mRNA than the ADX, ADX-Cort, and sham-operated control groups (P < 0.01).
conclusionsThese data demonstrate that glucocorticoids play a role in the postnatal maturation of the proximal tubule Na+/H+ antiporter activity and brush-border membrane NHE3 protein abundance. Glucocorticoid deficiency does not completely prevent the maturational increase in Na+/H+ antiporter activity and does not affect NHE3 mRNA abundance.
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