ArticleClinical and experimental immunology2001
Reactive oxygen intermediates, nitrite and IFN-gamma in Indian visceral leishmaniasis.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Quantification of Nitric Oxide and Reactive Oxygen Species inBio-protocol · 2019Article
- Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.International journal of nanomedicine · 2019Article
- A Defective Oxidative Burst and Impaired Antigen Presentation are Hallmarks of Human Visceral Leishmaniasis.Journal of clinical immunology · 2015Article
- Article
- Leishmania eukaryotic initiation factor (LeIF) inhibits parasite growth in murine macrophages.PloS one · 2014Article
- Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2012Article
- Identification of TLR inducing Th1-responsive Leishmania donovani amastigote-specific antigens.Molecular and cellular biochemistry · 2012Article
- Immunogenicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis.Vaccine · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen intermediates (ROI), nitrite and interferon-gamma (IFN-gamma) production were investigated at different times during treatment in 10 patients with visceral leishmaniasis (VL). Hydrogen peroxide (H2O2), superoxide (O2-) and IFN-gamma production by cultured monocytes from patients with active VL were significantly lower compared with the healthy controls. In contrast, nitrite levels in the supernatants from monocyte cultures of VL patients were comparable to healthy controls and increased significantly during antileishmanial therapy. On day 20 of treatment, a significant increase in the release of H2O2, O2- and IFN-gamma was observed. However, at follow-up, 4 months after the end of treatment, the production of H2O2, O2-, IFN-gamma and nitrite had declined significantly. Thus, the impairment in hydrogen peroxide and superoxide production suggests that down-regulation of these mediators may be involved in the reduced killing of parasites by monocytes of active VL patients. Furthermore, the monocytes regained respiratory burst activity as the antileishmanial therapy progressed, suggesting that an immune-based mechanism is involved in successful drug therapy.
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Registered trials
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