ArticleGlycoconjugate journal
'Heparin'--from anticoagulant drug into the new biology.
Article in Glycoconjugate journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- Multifaceted Heparin: Diverse Applications beyond Anticoagulant Therapy.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges.Marine drugs · 2021Review
- Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin.Materials (Basel, Switzerland) · 2021Article
- SAX-HPLC and HSQC NMR Spectroscopy: Orthogonal Methods for Characterizing Heparin Batches Composition.Frontiers in medicine · 2019Article
- The US regulatory and pharmacopeia response to the global heparin contamination crisis.Nature biotechnology · 2016Article
- Donor substrate promiscuity of the N-acetylglucosaminyltransferase activities of Pasteurella multocida heparosan synthase 2 (PmHS2) and Escherichia coli K5 KfiA.Applied microbiology and biotechnology · 2014Article
- Electrophoresis for the analysis of heparin purity and quality.Electrophoresis · 2012Review
- Divergent heparin oligosaccharide synthesis with preinstalled sulfate esters.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Control of the heparosan N-deacetylation leads to an improved bioengineered heparin.Applied microbiology and biotechnology · 2011Article
- Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes.Glycoconjugate journal · 2011Article
- Identification of a novel structure in heparin generated by potassium permanganate oxidation.Carbohydrate polymers · 2010Article
- Preactivation-based, one-pot combinatorial synthesis of heparin-like hexasaccharides for the analysis of heparin-protein interactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2010Article
- Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations.Analytical biochemistry · 2009Article
- Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation.Experimental cell research · 2008Article
- Conformation of heparin studied with macromolecular hydrodynamic methods and X-ray scattering.European biophysics journal : EBJ · 2003Article
- Progress in deciphering the information content of the 'glycome'--a crescendo in the closing years of the millennium.Glycoconjugate journalArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This overview attempts to cover, from a personal viewpoint, the development of the 'heparin' field during the last four decades. In particular, it emphasizes the metamorphosis of heparan sulfate (HS), from a disturbing contaminant in heparin production to the present-day key player in cell and developmental biology. Our understanding of the structural properties of the polysaccharides has been greatly promoted by studies of their biosynthesis. We now have a fairly detailed view of the various enzymatic reactions, that convert the initial [4GlcAbeta1-4GlcNAcalpha1-]n polymer into sulfated products with highly variable proportions of GlcA/IdoA and of N-acetyl, N-sulfate and O-sulfate substituents. It is also recognized that the variously substituted domains of the polysaccharide serve to interact, in more or less specific fashion, with a multitude of proteins, and that these interactions are essential to the biological functions of the proteins. Molecular genetics has unravelled the gene structures for almost all of the enzymes required to synthesize a heparin or HS chain, and has shown that several of these proteins exhibit genetic polymorphism. While differences in substrate specificity between enzyme isoforms may help to explain the structural variability of, in particular, HS chains, we still only partly understand the key features of heparin/HS biosynthesis and its regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.