ArticleNeoplasia (New York, N.Y.)
Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer.British journal of cancer · 2007Pooled it
- The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.British journal of cancer · 2005Guideline
- The Blood-prostate Barrier: An Obstacle to Drug Delivery into the Prostate.Current drug delivery · 2025Review
- Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential.British journal of cancer · 2021Article
- Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments.Neoplasia (New York, N.Y.) · 2019Article
- Albumin as a "Trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting.Biomaterials science · 2018Article
- Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging.Topics in magnetic resonance imaging : TMRI · 2016Review
- The Tumor Microenvironment Modulates Choline and Lipid Metabolism.Frontiers in oncology · 2016Article
- Multiscale and multi-modality visualization of angiogenesis in a human breast cancer model.Angiogenesis · 2014Article
- Permeability imaging in pediatric brain tumors.Translational pediatrics · 2014Review
- Water exchange-minimizing DCE-MRI protocol to detect changes in tumor vascular parameters: effect of bevacizumab/paclitaxel combination therapy.Magma (New York, N.Y.) · 2014Article
- Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models.American journal of nuclear medicine and molecular imaging · 2013Article
- Article
- Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer.Magnetic resonance in medicine · 2012Article
- Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.Oncogene · 2012Article
- Imaging hypoxia in gliomas.The British journal of radiology · 2011Review
- MRI of metastasis-permissive microenvironments.Future oncology (London, England) · 2011Review
- Functional phenotyping of the maternal albumin turnover in the mouse placenta by dynamic contrast-enhanced MRI.Molecular imaging and biology · 2011Article
- MR temperature imaging of nanoshell mediated laser ablation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2011Article
- Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy.Neuro-oncology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if human breast and prostate cancer xenografts preselected for differences in invasive and metastatic characteristics established correspondingly different vascular volume and permeability, quantified here with noninvasive MRI of the intravascular contrast agent albumin-GdDTPA. Tumor vascular volume and permeability of human breast and prostate cancer xenografts were characterized using MRI. Parallel studies confirmed the invasive behavior of these cell lines. Vascular endothelial growth factor (VEGF) expression in the cell lines was measured using ELISA and Western blots. Metastasis to the lungs was evaluated with spontaneous as well as experimental assay. Metastatic tumors formed vasculature with significantly higher permeability or vascular volume (P<.05, two-sided unpaired t test). The permeability profile matched VEGF expression. Within tumors, regions of high vascular volume usually exhibited low permeability whereas regions of low vascular volume exhibited high permeability. We observed that although invasion was necessary, without adequate vascularization it was not sufficient for metastasis to occur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.