ReviewOncogene2001
Methyl CpG binding proteins: coupling chromatin architecture to gene regulation.
Review in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed.
- Targeting the Tumor Epigenetic Regulator SETDB1 for Tumor Therapy.Current cancer drug targets · 2025Review
- Article
- MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts.Cancer gene therapy · 2024Article
- Epigenetic Factors and ncRNAs in Testicular Cancer.International journal of molecular sciences · 2023Review
- Aroma Components in Horticultural Crops: Chemical Diversity and Usage of Metabolic Engineering for Industrial Applications.Plants (Basel, Switzerland) · 2023Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- The landscape of CRISPR/Cas9 for inborn errors of metabolism.Molecular genetics and metabolism · 2023Review
- MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.Genome biology · 2022Article
- Why Do Some Vertebrates Have Microchromosomes?Cells · 2021Review
- MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge.Scientific reports · 2021Article
- Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells.Bioengineered · 2020Article
- Plant Volatile Organic Compounds Evolution: Transcriptional Regulation, Epigenetics and Polyploidy.International journal of molecular sciences · 2020Review
- Epigenetic Factors of Disease.Diseases (Basel, Switzerland) · 2019Article
- BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.Cancer cell · 2018Article
- Effects of arsenic toxicity beyond epigenetic modifications.Environmental geochemistry and health · 2018Review
- Dietary Modulation of the Epigenome.Physiological reviews · 2018Review
- Elevated methylation and decreased serum concentrations of BDNF in patients in levomethadone compared to diamorphine maintenance treatment.European archives of psychiatry and clinical neuroscience · 2017Article
- Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation.International journal of molecular sciences · 2016Review
- Transcription factors as readers and effectors of DNA methylation.Nature reviews. Genetics · 2016Review
- The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation.Epigenetics & chromatin · 2014Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A correlation between DNA methylation and transcriptional silencing has existed for many years. Recently, substantial progress has been reported in the search for proteins that interpret the regulatory information inherent in DNA methylation and translate this information into functional states, resulting in the identification of a family of highly conserved proteins, the MBD family. Direct connections between these proteins and histone modification enzymes have emerged as a common theme, implying that DNA methylation exerts its effects primarily through repressive chromatin architecture. Recent structural determinations of the DNA binding domain of two MBD family members, MeCP2 and MBD1, provide a framework to model the interactions of this family with DNA. Comparative sequence analysis and experimental DNA binding data can be interpreted using this structural framework allowing one to contrast the members of the MBD family with each other and to predict the properties of new family members. The identification of mutations in MeCP2, the founding member of this family, as causal for the neurological developmental disorder Rett Syndrome provides additional information regarding amino acid residues crucial to the functions of this interesting protein family.
Indexed as
Identifiers
11420733What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.