ReviewOncogene2001
Chromatin silencing and activation by Polycomb and trithorax group proteins.
Review in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 133 citations in OpenAlex.
- Transcriptional repression in stochastic gene expression, patterning, and cell fate specification.Developmental biology · 2022Article
- The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability.International journal of molecular sciences · 2021Review
- Phase 1 study of tazemetostat in Japanese patients with relapsed or refractory B-cell lymphoma.Cancer science · 2021Article
- Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy.Molecular cancer · 2020Review
- Enhancer of zeste homolog 2 (EZH2) inhibitors.Leukemia & lymphoma · 2018Review
- MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.Cold Spring Harbor perspectives in medicine · 2016Review
- Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression.Journal of experimental & clinical cancer research : CR · 2016Article
- Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts.Cell discovery · 2016Article
- Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal.EBioMedicine · 2016Article
- microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer.Oncotarget · 2015Article
- MiR-32 functions as a tumor suppressor and directly targets EZH2 in human oral squamous cell carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Transcriptional regulation by trithorax-group proteins.Cold Spring Harbor perspectives in biology · 2014Review
- The CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element (PRE).PloS one · 2014Article
- Article
- A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.Scientific reports · 2013Article
- EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.Cancer cell · 2013Article
- Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.Experimental hematology · 2013Article
- The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.Annual review of biochemistry · 2012Review
- Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?Genes & development · 2011Article
- Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human.The FEBS journal · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Polycomb group (PcG) of repressors and the trithorax group (trxG) of activators maintain the correct expression of several key developmental regulators, including the homeotic genes. PcG and trxG proteins function in distinct multiprotein complexes that are believed to control transcription by changing the structure of chromatin, organizing it into either a 'closed' or an 'open' conformation. The hallmark of gene regulation by PcG/trxG proteins is that it can lead to a mitotically stable pattern of gene expression, often referred to as epigenetic regulation. Although much remains to be learned, recent studies have provided insights into how this epigenetic switch is set, how PcG/trxG proteins might be linked to cis-acting DNA elements and what potential mechanisms underlie stable inheritance of gene expression status over multiple cell divisions. Finally, the study of the evolutionarily conserved PcG/trxG factors has recently gained additional urgency with the realization that they play a pertinent role in certain human cancers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.