ReviewOncogene2001
Chromatin remodeling: why it is important in cancer.
Review in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 115 citations in OpenAlex.
- Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer.Cancer discovery · 2026Article
- Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency.Epigenetics & chromatin · 2025Article
- Statistical relationships across epigenomes using large-scale hierarchical clustering.Bioinformatics advances · 2025Article
- Article
- Pancreatic INI1-deficient undifferentiated rhabdoid carcinoma achieves complete clinical response on gemcitabine and nab-paclitaxel following immediate progression on FOLFIRINOX: a case report.Journal of gastrointestinal oncology · 2021Article
- Analysis of endogenous and exogenous tumor upregulated promoter expression in canine tumors.PloS one · 2020Article
- Characterization of Histone Deacetylase Expression Within In Vitro and In Vivo Bladder Cancer Model Systems.International journal of molecular sciences · 2019Article
- Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers.Journal of the National Cancer Institute · 2018Article
- RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer.BioMedicine · 2018Article
- New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.Frontiers in molecular biosciences · 2017Review
- Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells.Oncogene · 2016Article
- Epigenetic Determinants of Cancer.Cold Spring Harbor perspectives in biology · 2016Review
- Ongoing challenges in the treatment of adenoid cystic carcinoma of the head and neck.Irish journal of medical science · 2015Review
- Rsf-1 overexpression serves as a prognostic marker in human hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Unraveling the regulatory connections between two controllers of breast cancer cell fate.Nucleic acids research · 2014Article
- Overexpression of Rsf-1 correlates with pathological type, p53 status and survival in primary breast cancer.International journal of clinical and experimental pathology · 2014Article
- The mutational landscape of adenoid cystic carcinoma.Nature genetics · 2013Article
- Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas.Human pathology · 2012Article
- Overexpression of a chromatin remodeling factor, RSF-1/HBXAP, correlates with aggressive oral squamous cell carcinoma.The American journal of pathology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A typical human cell expresses only a few thousand of the more than 30 000 genes contained within our chromosomes. The chromosomal infrastructure is essential for gene control, determining both active and repressed states. It is important not only to turn the right genes on but also to turn the right genes off. Histones and chromatin components have key roles in this decision making process. Mistakes have severe consequences. If as few as three inappropriate genes are turned off, a normal cell can be converted into a cancer cell. This epigenetic silencing of genes underlies a new approach to cancer therapy. Advances in the biochemistry and genetics of chromatin remodeling reveal that gene inactivation depends on the recruitment of enzymes that control the display of DNA within the chromosome. Mistargeting of these enzymes leads to tumorigenesis, but inhibition of their activity presents a novel approach to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.