ArticleOncogene2001
LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer.Oncology letters · 2019Review
- Article
- Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation.In vitro cellular & developmental biology. Animal · 2014Article
- Tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverse apoptotic signaling pathways.World journal of surgical oncology · 2013Article
- Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.Cellular and molecular life sciences : CMLS · 2013Article
- 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.World journal of surgical oncology · 2012Article
- The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.World journal of surgical oncology · 2012Article
- RBM10 Modulates Apoptosis and Influences TNF-α Gene Expression.Journal of cell death · 2012Article
- The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.Lung cancer (Amsterdam, Netherlands) · 2007Article
- The use of gene function to identify the rate-limiting steps controlling cell fate.Cancer immunology, immunotherapy : CII · 2004Review
- Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers.Oncogene · 2002Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. Overexpression of an alternative RNA splice variant of LUCA-15 has been shown to retard human Jurkat T cell proliferation and to accelerate CD95-mediated apoptosis. An antisense cDNA to the 3'-UTR of this splice variant was able to suppress CD95-mediated apoptosis. Here, we report that overexpression of LUCA-15 itself suppresses CD95-mediated apoptosis in Jurkat cells. This suppression occurs prior to the final execution stage of the CD95 signalling pathway, and is associated with up-regulation of the apoptosis inhibitory protein Bcl-2. LUCA-15 overexpression is also able to inhibit apoptosis induced by the protein kinase inhibitor staurosporine, but is not able to significantly suppress apoptosis mediated by the topoisomerase II inhibitor etoposide. These findings suggest that LUCA-15 is a selective inhibitor of cell death, and confirm the importance of the LUCA-15 genetic locus in the control of apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.