ArticleOncogene2001
Expression profiling and identification of novel genes in hepatocellular carcinomas.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 89 citations in OpenAlex.
- The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers.Frontiers in immunology · 2024Review
- A Molecular Hepatocellular Carcinoma Prognostic Score System Precisely Predicts Overall Survival of Hepatocellular Carcinoma Patients.Journal of clinical and translational hepatology · 2022Article
- Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells.Islets · 2022Article
- Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD.Journal of translational medicine · 2021Article
- Analysis of significant protein abundance from multiple reaction-monitoring data.BMC systems biology · 2018Article
- Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.Scientific reports · 2017Article
- Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.Journal of cancer research and clinical oncology · 2015Review
- p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.Biomedical reports · 2015Article
- Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.The Journal of biological chemistry · 2009Article
- Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate.Biochimica et biophysica acta · 2008Review
- Analysis of the mechanisms mediating tumor-specific changes in gene expression in human liver tumors.Cancer research · 2008Article
- The H19 non-coding RNA is essential for human tumor growth.PloS one · 2007Article
- Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.World journal of gastroenterology · 2005Article
- Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas.International journal of oncology · 2005Article
- DNA array-based gene profiling: from surgical specimen to the molecular portrait of cancer.Annals of surgery · 2005Review
- Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.Genes & development · 2004Article
- Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor.Genes & development · 2004Article
- Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index.The American journal of pathology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Liver cancer is the fifth most common cancer worldwide and unlike certain other cancers, such as colon cancer, a mutational model has not yet been developed. We have performed gene expression profiling of normal and neoplastic livers in C3H/HeJ mice treated with diethylnitrosamine. Using oligonucleotide microarrays, we compared gene expression in liver tumors to three different states of the normal liver: quiescent adult, regenerating adult, and newborn. Although each comparison revealed hundreds of differentially expressed genes, only 22 genes were found to be deregulated in the tumors in all three comparisons. Three of these genes were examined in human hepatocellular carcinomas and were found to be upregulated. As a second method of analysis, we used Representational Difference Analysis (RDA) to clone mRNA fragments differentially expressed in liver tumors versus regenerating livers. We cloned several novel mRNAs that are differentially regulated in murine liver tumors. Here we report the sequence of a novel cDNA whose expression is upregulated in both murine and human hepatocellular carcinomas. Our results suggest that DEN-treated mice provide an excellent model for human hepatocellular carcinomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.