ArticleOncogene2001
Identification of functional domains involved in BTG1 cell localization.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The role of BTG1 and BTG2 genes and their effects on insulin in poultry.Frontiers in physiology · 2024Article
- Article
- Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants.Biophysical journal · 2022Article
- Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.Animals : an open access journal from MDPI · 2021Review
- Tumor suppressors BTG1 and BTG2: Beyond growth control.Journal of cellular physiology · 2019Review
- Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables.BMC genomics · 2018Article
- BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers.Oncotarget · 2017Article
- Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer.Digestive diseases and sciences · 2015Article
- Multi-Trait GWAS and New Candidate Genes Annotation for Growth Curve Parameters in Brahman Cattle.PloS one · 2015Article
- Molecular cloning, sequence analysis, and cadmium stress-rated expression changes of BTG1 in freshwater pearl mussel (Hyriopsis schlegelii).Dong wu xue yan jiu = Zoological research · 2014Article
- BTG1 expression correlates with the pathogenesis and progression of ovarian carcinomas.International journal of molecular sciences · 2013Article
- C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.Oncogene · 2013Article
- Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation.Molecular and cellular biology · 2006Article
- Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.Oncogene · 2005Article
- Nuclear localization of Tob is important for regulation of its antiproliferative activity.Oncogene · 2004Article
- FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.The Journal of cell biology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that BTG1 stimulates myoblast differentiation. In addition, this protein displays a major nuclear localization in confluent myoblasts, decreasing during the early steps of differentiation, and is essentially detected in the cytoplasm of mature myotubes. To identify the domains involved in the cellular trafficking of BTG1, we observed the localization of several BTG1 sequences fused to betaGalactosidase. The highly conserved B box among all members of the BTG family induces a significant nuclear localization of the betaGal moiety, enhanced by presence of the BTG1 carboxy-terminal sequence. In addition, a functional Nuclear Export Signal (NES) overlaps the B box. Moreover, presence of the first 43 NH(2)-terminal amino acids reduced the nuclear localization of each chimeric protein tested. Last, the BTG1 amino-terminal domain bears an LxxLL motif favouring nuclear accumulation, and another region encompassing the A box inhibiting nuclear localization. In contrast to a BTG1 mutant exclusively localized in the cytoplasm, transient expression of a mutant displaying a nuclear localization enhanced myoblasts withdrawal from the cell cycle and terminal differentiation, thus mimicking the myogenic influence of BTG1. In conclusion, several regions of BTG1 are implicated in its cellular localization, and BTG1 myogenic activity is induced at the nuclear level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.