ArticleOncogene2001
N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Targeting Cancer Translational Plasticity: IRES-Driven Metabolism and Survival Within the Tumor Microenvironment.Cancers · 2025Review
- The MYCN 5' UTR as a therapeutic target in neuroblastoma.Cell reports · 2024Article
- A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells.Cellular and molecular life sciences : CMLS · 2022Article
- Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition.The EMBO journal · 2021Article
- Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1.Nucleic acids research · 2018Article
- L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis.Frontiers in molecular neuroscience · 2018Article
- Constitutive translation of human α-synuclein is mediated by the 5'-untranslated region.Open biology · 2016Article
- Cap-Independent Translational Control of Carcinogenesis.Frontiers in oncology · 2016Review
- Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation.Molecular oncology · 2015Article
- Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.Cell death and differentiation · 2014Article
- Cell type specificity and structural determinants of IRES activity from the 5' leaders of different HIV-1 transcripts.Nucleic acids research · 2013Article
- Translational control in cancer.Nature reviews. Cancer · 2010Review
- Article
- The human insulin receptor mRNA contains a functional internal ribosome entry segment.Nucleic acids research · 2009Article
- Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.Molecular and cellular biology · 2009Article
- Epigenetics in the nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Review
- Characterization of the internal IRES element of the zebrafish connexin55.5 reveals functional implication of the polypyrimidine tract binding protein.BMC molecular biology · 2008Article
- Potent activation of FGF-2 IRES-dependent mechanism of translation during brain development.RNA (New York, N.Y.) · 2008Article
- Sensing and integration of Erk and PI3K signals by Myc.PLoS computational biology · 2008Article
- Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic translation can be initiated either by a cap-dependent mechanism or by internal ribosome entry, a process by which ribosomes are directly recruited to structured regions of mRNA upstream of the initiation codon. We analysed the 5' untranslated region (UTR) of the proto-oncogene N-myc, and demonstrated by transfections in a dicistronic vector system that it contains a potent internal ribosome entry segment (IRES). The IRES is similar in length to the c-myc IRES and the activities of these IRESs are comparable in non-neuronal cells. Transfections were also carried out in cell lines derived from neuroblastomas, in which N-myc is expressed, and in a neuronal precursor cell line. In these cells the N-myc IRES is up to seven times more active than that of c-myc, suggesting that neuronal-specific non-canonical trans-acting factors are used by the N-myc but not the c-myc IRES. N-myc expression is increased by gene amplification in many neuroblastomas, but this is the first example of a translational mechanism by which N-myc expression could be further increased. The discovery of an IRES that displays enhanced activity in neuronal cell lines has important potential as a tool for protein expression in neural tissue.
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