ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2001
The battle of the sexes after fertilization: behaviour of paternal and maternal chromosomes in the early mammalian embryo.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective.Biomedicines · 2022Review
- Altered three-dimensional organization of sperm genome in DPY19L2-deficient globozoospermic patients.Journal of assisted reproduction and genetics · 2019Article
- A reverse transcriptase-dependent mechanism is essential for murine preimplantation development.Genes · 2011Article
- Parental genomes mix in mule and human cell nuclei.Chromosoma · 2009Article
- Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes.Epigenetics & chromatin · 2008Article
- Epigenetic programming in the preimplantation rat embryo is disrupted by chronic paternal cyclophosphamide exposure.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The effect of interspecific oocytes on demethylation of sperm DNA.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Non-random positioning of chromosomes in human sperm nuclei.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- Conservation of chromosome arrangement and position of the X in mammalian sperm suggests functional significance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the early diploid mammalian embryo, a father's chromosomes don't mix with the mother's until some time after fertilization. This topological genome separation is preserved up to the four-cell embryo stage and then gradually disappears. Unlike maternal DNA, sperm DNA arrives in an almost crystalline structure, heavily modified with methylcytosines (MeCs), which keep genes inactive. Compartmentalization of the nucleus according to parental origin may make it easier for the cellular machinery of the fertilized egg to revive the paternal chromosomes and to control paternal gene expression. Active zygotic demethylation of the paternal genome by a putative demethylase in the egg is a striking example for the battle of the sexes at the genomic level and beyond the single-gene level. It has important implications for genomic imprinting, and the establishment of genetic totipotency in fertilized eggs and in somatic cells during mammalian cloning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.