ReviewImmunologic research2001
Neutrophil oscillations: temporal and spatiotemporal aspects of cell behavior.
Review in Immunologic research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis.Frontiers in immunology · 2025Article
- Regulation of Neutrophil NADPH Oxidase, NOX2: A Crucial Effector in Neutrophil Phenotype and Function.Frontiers in cell and developmental biology · 2022Review
- Rhythmicity and waves in the cortex of single cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators.Frontiers in pharmacology · 2016Review
- A third measure-metastable state in the dynamics of spontaneous shape change in healthy human's white cells.PLoS computational biology · 2011Article
- A method for determining the robustness of bio-molecular oscillator models.BMC systems biology · 2009Article
- Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.Arthritis and rheumatism · 2009Article
- Oscillatory NAD(P)H waves and calcium oscillations in neutrophils? A modeling study of feasibility.Biophysical journal · 2009Article
- Reactive oxygen species in phagocytic leukocytes.Histochemistry and cell biology · 2008Review
- Neutrophils: the forgotten cell in JIA disease pathogenesis.Pediatric rheumatology online journal · 2007Article
- Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach.Biophysical journal · 2007Article
- Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses.European biophysics journal : EBJ · 2005Article
- Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase.The Biochemical journal · 2005Article
- Changes of cytosolic [Ca2+]i in neutrophils in pancreatic microcirculation of rats with caerulein-induced acute pancreatitis under fluid shear stress.World journal of gastroenterology · 2004Article
- Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments.The Journal of general physiology · 2004Article
- Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes.European biophysics journal : EBJ · 2004Article
- A model of the oscillatory metabolism of activated neutrophils.Biophysical journal · 2003Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
- Apparent role of traveling metabolic waves in oxidant release by living neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil activation is an essential event in inflammatory responses. How cells coordinate, integrate, manage, and distribute information on physiologically-relevant timescales are not well understood. Although neutrophil oscillators have been known for many years, their biological roles have not been identified. We suggest that intracellular oscillators (such as NAD(P)H, pH, calcium, and so on) account for functional oscillations (e.g., superoxide and NO production, cytolytic marker release, pericellular proteolysis, and actin assembly). In addition to these well-known temporal oscillations, we have recently discovered self-organized traveling chemical waves in neutrophils; these waves respond to extracellular signals and have distinct origins that coincide with a cell's uropod, lamellipodium, or adherence site. The fundamental physico-chemical features of cell chemistry will have an increasing role in our understanding of leukocyte function.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.