ArticleProceedings of the National Academy of Sciences of the United States of America2001
Multilocus analysis of extracellular putative virulence proteins made by group A Streptococcus: population genetics, human serologic response, and gene transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- The Slr protein of Streptococcus pyogenes is selectively expressed in vivo and is a target for protective antibodies.EMBO molecular medicine · 2026Article
- The exploitation of human glycans by Group A Streptococcus.FEMS microbiology reviews · 2022Article
- New insights into histidine triad proteins: solution structure of a Streptococcus pneumoniae PhtD domain and zinc transfer to AdcAII.PloS one · 2013Article
- Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.Molecular microbiology · 2011Article
- Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine.Infection and immunity · 2010Article
- Regulation of polysaccharide utilization contributes to the persistence of group a streptococcus in the oropharynx.Infection and immunity · 2007Article
- Growth phase-dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes.Antimicrobial agents and chemotherapy · 2007Article
- Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB.FEMS immunology and medical microbiology · 2006Article
- The streptococcal Blr and Slr proteins define a family of surface proteins with leucine-rich repeats: camouflaging by other surface structures.Journal of bacteriology · 2006Article
- Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion.Microbiology and molecular biology reviews : MMBR · 2004Review
- Stable association between strains of Mycobacterium tuberculosis and their human host populations.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.Infection and immunity · 2004Article
- Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins.Infection and immunity · 2003Article
- Group A Streptococcus gene expression in humans and cynomolgus macaques with acute pharyngitis.Infection and immunity · 2003Article
- Streptococcus pyogenes glycoprotein-binding strepadhesin activity is mediated by a surface-associated carbohydrate-degrading enzyme, pullulanase.Infection and immunity · 2003Article
- Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks.Infection and immunity · 2002Article
- Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response.Journal of bacteriology · 2002Article
- Differential expression of virulence-related genes in Enterococcus faecalis in response to biological cues in serum and urine.Infection and immunity · 2002Article
- Microtiter plate assay for assessment of Listeria monocytogenes biofilm formation.Applied and environmental microbiology · 2002Article
- Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Species of pathogenic microbes are composed of an array of evolutionarily distinct chromosomal genotypes characterized by diversity in gene content and sequence (allelic variation). The occurrence of substantial genetic diversity has hindered progress in developing a comprehensive understanding of the molecular basis of virulence and new therapeutics such as vaccines. To provide new information that bears on these issues, 11 genes encoding extracellular proteins in the human bacterial pathogen group A Streptococcus identified by analysis of four genomes were studied. Eight of the 11 genes encode proteins with a LPXTG(L) motif that covalently links Gram-positive virulence factors to the bacterial cell surface. Sequence analysis of the 11 genes in 37 geographically and phylogenetically diverse group A Streptococcus strains cultured from patients with different infection types found that recent horizontal gene transfer has contributed substantially to chromosomal diversity. Regions of the inferred proteins likely to interact with the host were identified by molecular population genetic analysis, and Western immunoblot analysis with sera from infected patients confirmed that they were antigenic. Real-time reverse transcriptase-PCR (TaqMan) assays found that transcription of six of the 11 genes was substantially up-regulated in the stationary phase. In addition, transcription of many genes was influenced by the covR and mga trans-acting gene regulatory loci. Multilocus investigation of putative virulence genes by the integrated approach described herein provides an important strategy to aid microbial pathogenesis research and rapidly identify new targets for therapeutics research.
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